Protein Alignment Cul6 and cul-6

DIOPT Version :9

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_502412.1
• Gene: cul-6 / 178214
• WormBaseID: WBGene00000841
• Length: 729
• Species: Caenorhabditis elegans
• Alignment Length: 735
• Identity: 174/735 - (23%)
• Similarity: 299/735 - (40%)
• Gaps: 140/735 - (19%)

  Fly    41 MHLYHLIYKQCA----AERNWNNPAQKNGRSLYIVLSDCLMKRLKN------IAWVMENQLDDNK 95
            |.||..:|..|.    |..|.|:|.         ..|:.|.|:|:|      ||  :.:::....
 Worm    29 MMLYDAVYNICTTTTLANSNNNSPE---------FASEFLYKQLENYIRTYVIA--IRDRISACS 82

  Fly    96 PIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAMISWKELVFE--P 158
            ...|:.|....|..::.|....|....:.|||:|.::....:.|...||:||:..||...|:  .
 Worm    83 GDELLGKCTIEWDNFKFSTRICNCIFQYLNRNFVSKKVEDKNGEIVEIYKLALDIWKAEFFDNFK 147

  Fly   159 SVTILAAIRLILSQMPREYNKSLEYQVYQVLQSIVELYANDKYQDVSLPSRID--KIF------- 214
            ..||.|.:.|||  :.|..:......:..|::.:.||   |.|:....|..:|  |:|
 Worm   148 VKTIDAILELIL--LERCGSTINSTHISSVVECLTEL---DIYKVSFEPQFLDATKLFYKQEVLN 207

  Fly   215 -TEKVMDF------------YKS----------TTLHEFQKIVVSNDYKDFKHFLRYACLAMPEI 256
             .|.|:::            |:|          ..:...:.|::|:..| |.|......|...:.
 Worm   208 SKETVIEYMITVENRLFQEEYRSRRYLGPSTNDLLIDSCESILISDRLK-FLHSEFERLLEARKD 271

  Fly   257 ENGTQFKAILKR----------YLAARL----QET----------RLSGKDYIQAFL-------- 289
            |:.|:..::.:|          ||..|:    .||          :.:.|:||...|
 Worm   272 EHLTRMYSLCRRVTHGLEDLRVYLEKRILKEGHETLQRLAKDSGLKTTPKEYITKLLEVHEIYFN 336

  Fly   290 ---------GLCRGPLQRALRDHTKLAEVVDAVCKEEINRKGQIIDPTRLLVTYANELMTKRQE- 344
                     .|....|.:|.:|..: |..|..:..|: :|..:..|   .|..|.::|:.|..:
 Worm   337 LINKAFDRNALFMQSLDKASKDFIE-ANAVTMLAPEK-HRSTRSAD---YLARYCDQLLKKNSKV 396

  Fly   345 SEEAIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTR 409
            .:|..:|:...::|   ::|::..|...|......|.||.:|.||..|....:.|........||
 Worm   397 QDETALDKALTVLK---YISEKDVFQLYYQNWFSERIINNSSASDDAEEKFITNLTATEGLEYTR 458

  Fly   410 CIYVQLRDVDKLRTLKKEFQDHLNSKGIKLGFDFRPKCFKNDG---SFENFNLTLPDELQQAWKE 471
            .:...:.|....:.|..||:|....|.|    ||. ...:..|   |.:...:.||.||....||
 Worm   459 NLVKMVEDAKISKDLTTEFKDIKTEKSI----DFN-VILQTTGAWPSLDQIKIILPRELSTILKE 518

  Fly   472 FRIFYEARKLQSKAIIQLNNELSS--GEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELV 534
            |..||.|    |....:||...|.  ||:.....:..|:..|:..|:..|.|||..:.||.:::.
 Worm   519 FDTFYNA----SHNGRRLNWAYSQCRGEVNSKAFEKKYVFIVTASQLCTLYLFNEQDSFTIEQIS 579

  Fly   535 TALGVELETLQEALKQIKFLV--YIEVNKVN---------YIEINMDFTNRKRRLFCNEPLPRKM 588
            .|:.:..::....:..:..::  .:.|:|.|         .:.:|..:.|:|.|:.....: :|.
 Worm   580 KAIEMTAKSTSAIVGSLNPVIDPVLVVDKGNEKDGYPPDAVVSLNTKYANKKVRVDLTTAI-KKA 643

  Fly   589 RKIEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDY 651
            ....|...::..:..|:  ::.|.||||||.:|.|.::.||:.:..:||.|..|.|..||..::.
 Worm   644 TADRETDAVQNTVESDRKYEIKACIVRIMKTRKSLTHTLLINEIISQLKSRFTPNVQMIKICIEI 708

  Fly   652 LVEREYLER-DNYYNIYRYL 670
            |:|:.|:.| :|.:|:|.||
 Worm   709 LIEQLYIRRSENEHNVYEYL 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	172/733 (23%)
		CULLIN	362..500	CDD:214545	40/142 (28%)
		Cullin_Nedd8	606..661	CDD:287520	22/55 (40%)
cul-6	NP_502412.1	Cullin	10..596	CDD:279260	137/600 (23%)
		CULLIN	411..547	CDD:214545	40/144 (28%)
		Cullin_Nedd8	656..723	CDD:214883	24/66 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1033
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0003709
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.830