Protein Alignment Cul6 and cul-4

DIOPT Version :9

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_495525.2
• Gene: cul-4 / 174198
• WormBaseID: WBGene00000839
• Length: 840
• Species: Caenorhabditis elegans
• Alignment Length: 787
• Identity: 165/787 - (20%)
• Similarity: 309/787 - (39%)
• Gaps: 212/787 - (26%)

  Fly    17 LIDNILQVVNQIFDD---YTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMK 78
            |.||:.    .|.:|   .|:.:|     |:..:...|  ::|.:.           ||.|.|:.
 Worm   125 LSDNVF----AILEDRKTVTTLEG-----LFSKVRSVC--DKNQSK-----------VLYDRLVA 167

  Fly    79 RLKNIAWVMENQLDDNKPIRL----IAKYLEH----WVPYQRSCEKLNLACYHFNRN-WVERERL 134
            .:...|..::..|:..:.:.|    ..:|||.    |..|.   .|:||.     || ::..:|:
 Worm   168 IVVQFAKSLKESLNAVEQVPLAEDNCEQYLEKFGQIWQAYP---VKINLI-----RNIFLHLDRI 224

  Fly   135 ---KGDKETYPIYRLAMISWKELVFEPSVTILAAIRLILSQMPREYNKS-LEYQVYQVLQSIVEL 195
               ..|.|..|::...|..:::..| |::.             :|:..: |...:|..:|.|::.
 Worm   225 ALGATDTEILPLWECFMQIFQKTFF-PNIF-------------KEFKATKLFNALYMAMQKIMQR 275

  Fly   196 YANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVS-------------------NDYKD 241
            |..|.    .|.|.:|.:.|..|.:        ||.|.::|                   |||.:
 Worm   276 YPVDS----PLRSLVDMLQTVHVSE--------EFAKFLISQLREHYNNERIDKVPKMNCNDYME 328

  Fly   242 F--KHFLRYA----------------------CL---AMPEI----------------------- 256
            :  ....||:                      ||   |:|||
 Worm   329 YCEDQINRYSQLVKVNFDEPSALKDVQATVTNCLIQQAIPEILTHDFDDLIDSDNISDIGRMFNL 393

  Fly   257 ---------ENGTQFKAILKRYLAARLQETRLSGKDYIQAFLG-------LCRGPLQRALRDHTK 305
                     |..|||...||: ...:|..| ...:|.:...|.       :..|..:.| .|..|
 Worm   394 CRQCVGGEDEVRTQFSKYLKK-RGEKLIAT-CPDEDLVSELLAFKKKVDFIMTGSFKSA-NDPVK 455

  Fly   306 LAEVVDAVCKEEINRKGQIIDPTRLLVTYANELM--TKRQESEEAIIDEL-KRIVKCVEFLSDEY 367
            :.:.:....:..:|:  |:.....|:..:.:.|:  :.:..|::..:|:: ...:....:|..:.
 Worm   456 MRQCLSDAFESFVNK--QVDRSAELISKHFHTLLHSSNKNVSDDTTLDQMVDEAIVLFRYLRGKD 518

  Fly   368 KFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRT---LKKEFQ 429
            .|...|.:.|..|...|.|.|...|.::...|..:..:..|..:....:|:|....   |..::.
 Worm   519 VFEAYYKRGLAKRLFLERSASVDAEKMVLCKLKTECGSAFTYKLEGMFKDMDASENYGRLFNQYL 583

  Fly   430 DHLNSKGIKLGFDFR---PKCFKNDGSFENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNN 491
            :|:|.:  |..|..|   |:.:.   :::.:.:.:|.|::....:::.||  |.......::.::
 Worm   584 EHMNKE--KANFTARVITPEYWP---TYDTYEINIPKEMRDTLTDYQDFY--RVQHGNRNVKWHH 641

  Fly   492 ELSSGEITCHLNQSVYILEVSTL-QMAVLMLFNRHERFTEQELVTALGV-ELETLQEALKQI--- 551
            .|:|..|:...........::|: |..:|:|||:.|.:|..|:|....: |:|.::..|..:
 Worm   642 GLASAVISASFRPGCKKELIATMYQTVILLLFNKCETWTVAEIVEHTKILEIEVVKNVLALLGGR 706

  Fly   552 ---KFLVYIE----VNKVNYIE--------INMDFTNRKRRLFCNEPLPRKMRK--IEEKSEIEL 599
               |.|..:|    ..|...:|        :|..||.::    |...:.:...|  :||..|::.
 Worm   707 DKPKVLQRVEGGGSEKKEGTVENLKNEKFVVNSKFTEKR----CRVRIAQVNIKTAVEETKEVKE 767

  Fly   600 KIRRDKQ--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERD- 661
            ::..|:|  :|||:|||||.:|||.:..|::.:.::|  |.....:.|||||:.|:||||:.||
 Worm   768 EVNSDRQYKIDAAVVRIMKARKQLNHQTLMTELLQQL--RFPVSTADIKKRLESLIEREYISRDP 830

  Fly   662 ---NYYN 665
               :.||
 Worm   831 EEASSYN 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	162/779 (21%)
		CULLIN	362..500	CDD:214545	28/143 (20%)
		Cullin_Nedd8	606..661	CDD:287520	25/56 (45%)
cul-4	NP_495525.2	Cullin	123..740	CDD:279260	128/682 (19%)
		PKc_like	<253..336	CDD:304357	19/107 (18%)
		CULLIN	513..652	CDD:214545	28/145 (19%)
		Cullin_Nedd8	774..831	CDD:287520	27/58 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820