DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and CACUL1

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_722517.3	Gene:	CACUL1 / 143384	HGNCID:	23727	Length:	369	Species:	Homo sapiens

Alignment Length:	249	Identity:	49/249 - (19%)
Similarity:	97/249 - (38%)	Gaps:	42/249 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRVKRISNYFDSMLPLIDNIL-QVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKN 64
            || |..|.:|..:..|.:|..: |::.|...||.....::   :|..:|| |.        .|::
Human   124 MN-VITIEDYKSTYWPKLDGAIDQLLTQSPGDYIPISYEQ---IYSCVYK-CV--------CQQH 175

  Fly    65 GRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWV 129
            ...:|   || |:|::.|....:..:|..:.|...|.::......|..:.:.:.....:.|:.::
Human   176 SEQMY---SD-LIKKITNHLERVSKELQASPPDLYIERFNIALGQYMGALQSIVPLFIYMNKFYI 236

  Fly   130 E---RERLKGDKETYPIYRLAMISWKELVFEPSVTILAAIRLILSQMPREYNKSLEYQVYQVLQS 191
            |   ...||.|     :.:|    :.|.|.|..:..|..:.|.....|.:...|....:.:.|.:
Human   237 ETKLNRDLKDD-----LIKL----FTEHVAEKHIYSLMPLLLEAQSTPFQVTPSTMANIVKGLYT 292

  Fly   192 I----VELYAN--DKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDY 239
            :    |::...  .|:....||..::...:|......|      ||:.::.|.:
Human   293 LRPEWVQMAPTLFSKFIPNILPPAVESELSEYAAQDQK------FQRELIQNGF 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	41/224 (18%)
		CULLIN	362..500	CDD:214545
		Cullin_Nedd8	606..661	CDD:287520
CACUL1	NP_722517.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		Cullin	138..>256	CDD:279260	28/142 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..369
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900