Protein Alignment Cul6 and Cul1

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: XP_061518789.1
• Gene: Cul1 / 1277942
• VectorBaseID: AGAMI1_005719
• Length: 778
• Species: Anopheles gambiae
• Alignment Length: 788
• Identity: 200/788 - (25%)
• Similarity: 336/788 - (42%)
• Gaps: 180/788 - (22%)

  Fly    25 VNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNP------------------AQKNGRSLYIV 71
            :.|::....|....:.|.||..:|..|.:.....|.                  ||..|:.||
Mosquito    28 IKQVYKRELSLGIARYMELYTHVYNYCTSVHQQPNSRTGSSKISKKGISAPPGGAQLVGQELY-- 90

  Fly    72 LSDCLMKRLKNIAWVMENQLDDNKPIRL------------IAKYLEHWVPYQRSCEKLNLACYHF 124
                  ||||..   :||.|     :||            ::.|.:.|..||.|.:.||..|.:.
Mosquito    91 ------KRLKEF---LENYL-----VRLHQNGIDLMDEEVLSFYTKRWEEYQFSSKVLNGVCAYL 141

  Fly   125 NRNWVERERLKGDKETYPIYRLAMISWKELVFE---PSVTILAAIRLILSQMPREYN-KSLEYQ- 184
            ||:||:||..:|.|:.|.||:||:::|:..:|:   ..||     ..:|..:.||.| :::..:
Mosquito   142 NRHWVKRECEEGRKDVYEIYQLALVTWRGNLFKHLNKQVT-----NAVLKLIERERNGETINSRL 201

  Fly   185 VYQVLQSIVELYAND-----KYQDVSL-PSRIDKIFTEKVMDFYKSTT----------------- 226
            |..|:...|||..|:     |.|::|: ....:.||.|....||...:
Mosquito   202 VSGVINCYVELGLNEDDPHAKGQNLSVYKESFENIFLEDTERFYTRESAEFLRENPVTEYMKRVE 266

  Fly   227 -------------LH-------------------------EFQKIVVSNDYKDFKHFLRYACLAM 253
                         ||                         |||.::.|:..:|....  |:.:|
Mosquito   267 LRLNEEQKRVQVYLHESTLDRLAEKCERVLIHIHLDQFRTEFQNLLNSDKNQDLGRM--YSLVA- 328

  Fly   254 PEIENGT-QFKAILKRYL----AARLQETRLSG----KDYIQAFLGLCR---GPLQRALRDHTKL 306
             .|:.|. :.|.||:.::    .|.:::...|.    |.|:|..|.:.:   ..:..|..:.:..
Mosquito   329 -RIKAGLYELKEILETHIHNQGLAAIEKCGDSAVNDPKIYVQTILEVHKKYNALVLTAFNNDSGF 392

  Fly   307 AEVVDAVCKEEINRKGQIIDPTR-------LLVTYANELMTKRQES-EEA-IIDELKRIVKCVEF 362
            ...:|..|.:.||... :.:.:|       ||..|.:.|:.|..:: ||| :.|.|.:::...::
Mosquito   393 VAALDKACGKFINTNA-VTELSRSASKSPELLAKYCDLLLKKSSKNPEEAELEDTLNQVMVVFKY 456

  Fly   363 LSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDV--------- 418
            :.|:..|...|.|.|..|.....|.||..|:.|.|.|.:......|..:....:|:
Mosquito   457 IEDKDVFQKFYSKMLAKRLCQHMSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNDQ 521

  Fly   419 -----DKLRTLKKEFQDHLNSKGIKLGFDFRPKCFKNDGSF---ENFNLTLPDELQQAWKEFRIF 475
                 :|||..:...|:.::...:.|          :.||:   :.|..:||.||:|:...|..|
Mosquito   522 YRKHHEKLRDTRSTTQNEIDFSILVL----------SSGSWPFGQGFTFSLPFELEQSVHRFNNF 576

  Fly   476 YEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVE 540
            | |::...:.:..|.| :..||:..:..:..|.|:.||.|||||:.||....::.::|....|:.
Mosquito   577 Y-AKQHSGRKLNWLYN-MCRGELITNCFRMRYTLQASTFQMAVLLQFNEETAWSIKQLGENTGIN 639

  Fly   541 LETLQEALK---QIKFLVYIE----VNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIE 598
            .|.|.:.|.   :.|.|...|    ::..:.||:|.||.|||.|:..|.||..:::..:|.:...
Mosquito   640 NENLIQVLPILLKTKLLNCYEGEGKLHPDSTIELNKDFKNRKLRININFPLKSELKVEQEATHKN 704

  Fly   599 LKIRRDKQVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLER-DN 662
            ::..|...:.||||||||.:|.|.:::|::.|..:|..|.||::..|||.:|.|:|:||||| :.
Mosquito   705 IEEDRKILIQAAIVRIMKMRKMLNHTQLVNEVLNQLSTRFKPKIQVIKKCIDILIEKEYLERQEG 769

  Fly   663 YYNIYRYL 670
            ..:.|.||
Mosquito   770 QKDTYSYL 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	198/786 (25%)
Cul1	XP_061518789.1	None