Protein Alignment Cul6 and Cul5

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: XP_312548.6
• Gene: Cul5 / 1273558
• VectorBaseID: AGAMI1_004198
• Length: 825
• Species: Anopheles gambiae
• Alignment Length: 667
• Identity: 146/667 - (21%)
• Similarity: 262/667 - (39%)
• Gaps: 185/667 - (27%)

  Fly   143 IYRLAMISWKELVFEPSVTIL--AAIRLILSQMPRE-YNKSLEYQVYQVLQSIVELYANDKYQDV 204
            :.:|.:.||.:.:|......|  :|::|:.::...| ::..|   |..|.:|.|.|.:|.:
Mosquito   187 VRKLMLDSWNQSIFMNIKHRLQESAMKLVHAERNGEAFDSQL---VIGVRESYVNLCSNTE---- 244

  Fly   205 SLPSRIDKIFTEKVMDFYKSTTLH---EFQKIVVSNDYK--DFKHFLRYACLAMPEIENGTQFKA 264
                  ||:  |...:.:::..||   .|.::..|...:  ..|.|:.||...:.|.|      |
Mosquito   245 ------DKL--EIYRENFEAAYLHATSAFYRLKASEQLQTNGVKSFMEYADAKLREEE------A 295

  Fly   265 ILKRYL-------AARLQETRLSGKDYIQAFLGLCR-------------------------GPLQ 297
            ..:|||       ..:...|.|.| |::...|..|.                         .|:.
Mosquito   296 RGERYLEPGSITALGQCCVTVLIG-DHLPTLLAECAPLIEARETQRLQLMFRLLDRVAGGVDPML 359

  Fly   298 RALRDHTKLAEVVDAVCKEEINRKGQIIDPTRLLVTYAN-------------ELMTKRQESEEAI 349
            |.|.:|...|.:.|.|...:|..:.......|||..:..             ..:|.|.::.:.:
Mosquito   360 RDLENHIVQAGLADMVAAADIITQDSEKYVERLLKLFRRFSDLVKEAFNDDPRFLTARDKAFKTV 424

  Fly   350 IDELKRI---------------------VKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVES 393
            ::::...                     .||.|.|::   :.||   .||....::..|::.:||
Mosquito   425 VNDITLFKLELPTSNTAMARGIKISTPESKCPELLAN---YCDM---LLRRTPFSKRLTTEEIES 483

  Fly   394 IMYSLL-------NKKM------ANFVTRCIYVQ-------------LRDV----DKLRTLKKEF 428
            .:..:|       ||.:      |:...|.|...             ||:|    |.:..|.:.|
Mosquito   484 RLKDVLLVLKYVSNKDVFMRYHKAHLTRRLILDSSADSEKEEDMVEWLREVGMPADYVNKLARMF 548

  Fly   429 QDHLNSKGIKLGFD----FRPKCFKND--------------GSFENFNLTLPDELQQAWKEFRIF 475
            ||      ||:..|    ||.:..::|              || |..:::||.||:....|...|
Mosquito   549 QD------IKVSEDLNTQFRSQTTRHDAINIKILNAGAWARGS-ERVSVSLPLELEDYIPEVEEF 606

  Fly   476 YEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNR--HERFTEQELVTALG 538
            |  :|..|...:|..:.:|:|.||...|...:.|:|:|.|||||..:|:  :|:.:.:.|..|..
Mosquito   607 Y--KKKHSGRKLQWYHHMSNGTITFANNTGRFDLDVTTFQMAVLFAWNQRPNEKVSYENLRLATE 669

  Fly   539 VELETLQEALKQI--------KFLVYIEV--NKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEE 593
            :....|:..|..:        :.|||...  |..::.|..:.:.|::..:..|.. |::..|:..
Mosquito   670 LPDPELRRTLWSLVAFPKLKRQLLVYEPAISNPKDFTENTLFWVNQEFAIIKNGK-PQRRGKVNL 733

  Fly   594 KSEIELKIRRDKQVD-------------AAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFI 645
            ...::|...|.:|.|             .||::|||.:|:|..:.|.:.:.:.||:...|....|
Mosquito   734 VGRLQLSTERSQQEDNQSIVQLRILRTQEAIIKIMKMRKRLSNAALQAELVDILKNMFLPSKKMI 798

  Fly   646 KKRLDYLVEREYLERDN 662
            |::|::|:|.:|:.||:
Mosquito   799 KEQLEWLIEHKYMRRDD 815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	146/667 (22%)
Cul5	XP_312548.6	None