Protein Alignment Cul6 and cul2

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: XP_002935209.2
• Gene: cul2 / 100492608
• XenbaseID: XB-GENE-960931
• Length: 766
• Species: Xenopus tropicalis
• Alignment Length: 825
• Identity: 163/825 - (19%)
• Similarity: 309/825 - (37%)
• Gaps: 225/825 - (27%)

  Fly     1 MNRVKRISNYFDSMLPLIDNILQVV----------NQIFDDYTSFDGQKLMHLYHLIYKQCAAER 55
            |:...|:.::.::...|:..|..||          |..|.|               ||..|.|
 Frog     1 MSLKPRVVDFDETWNKLLTTIKAVVMLDYVERATWNDRFSD---------------IYALCVA-- 48

  Fly    56 NWNNPAQKNGRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLA 120
             :..|.   |..||......|...::.:   ....||..:  :::..|..:|..|.|..:.::..
 Frog    49 -YPEPL---GERLYTETKIFLENHVQQL---HTRVLDSAE--QVLVMYYRYWEEYSRGADYMDCL 104

  Fly   121 CYHFNRNWVERERLKGDKETY------------PIYRLAMISWKELVFEPSVTILAAIRLILSQM 173
            ..:.|..::::.:|......|            .|..||:..|::|:.||....|  :|::|.::
 Frog   105 YRYLNTQYIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDLWRKLMIEPLQDTL--LRMLLKEI 167

  Fly   174 PR-----------------------EYNKSLEYQVYQVLQSIVELYANDKY--QDVS--LPSRID 211
            .|                       :|.|....:.||.:..:..|....:|  |:.|  |.....
 Frog   168 KRDRCGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFELPFLAETGEYYKQEASNLLQESNC 232

  Fly   212 KIFTEKVMDFYK---------------STTLHEFQKIVVSNDYKDFKH----------------- 244
            ..:.||::...|               :..:||.|:.:|: |:..|.|
 Frog   233 SQYMEKILGRLKDEEIRCRKYLHPSSYNKVIHECQQRMVA-DHLQFLHAECHNIIRQERRSDMAN 296

  Fly   245 ---FLRYACLAMP----EIENGTQ---FKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRA 299
               .||.....:|    |::|...   .:||           :.||.::....|       ::..
 Frog   297 MYTLLRAVSNGLPHMIQELQNHIHDEGLRAI-----------SNLSQENMPTQF-------VESV 343

  Fly   300 LRDHTKLAEVVDAV----------------CKEEINRKGQIIDPTRLLVTYANELMTKRQE--SE 346
            |..|:|..::|::|                |.........:.....||..|.:.::.|..:  :|
 Frog   344 LEVHSKFVQLVNSVLNGDQHFMSALDKALTCVVNYREPKSVCKAPELLAKYCDNMLKKSAKGMTE 408

  Fly   347 EAIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCI 411
            ..:.|:|...:...:::.|:..|...|.:.|..|.|:..|.|...|..|.:.|.:......|..:
 Frog   409 NEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEETMINKLKQACGYEFTSKL 473

  Fly   412 YVQLRDVDKLRTLKKEFQDHLNSKG--IKLGFDFR---------PKCFKNDGSFENFNLTLPDEL 465
            :....|:.....|..:|.:.:.::.  |.||..|:         |.......:|     .:|.||
 Frog   474 HRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTF-----AIPQEL 533

  Fly   466 QQAWKEFRIFY----EARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHE 526
            :::.:.|.:||    ..|||      ...:.|.:||:..:.....|:..|:|.|||||:.||..|
 Frog   534 EKSVQMFELFYNQHFSGRKL------TWLHYLCTGEVKMNYLCKPYVAMVTTYQMAVLLAFNNSE 592

  Fly   527 RFTEQELVTALGVELETLQEALKQIKFLVYIEVNKVNY------------IEINMDFTNRKRRLF 579
            ..|.:||..:..:..:.|.:.:|.:     ::|..:|:            ..:||:|::::.:..
 Frog   593 IVTYKELQDSTQMNEKELTKTIKSL-----LDVKMINHDSDKEDIDGESTFSLNMNFSSKRTKFK 652

  Fly   580 CNEPLPR--------------KMRKIEEKSEIELK-----IRRDKQ--VDAAIVRIMKGQKQLEY 623
            ...|:.:              .:.:.|.:..:|::     :..|::  :.||||||||.:|.|.:
 Frog   653 ITTPMQKDTPQGAQPTCAEEAMLWRGERRFSLEVEQTRSAVDEDRKMYLQAAIVRIMKARKILRH 717

  Fly   624 SELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLER-----DNY 663
            :.||..|..:.:.|..|.:|.|||.::.|::::|:||     |.|
 Frog   718 NALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEY 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	158/801 (20%)
cul2	XP_002935209.2	Cullin	14..644	CDD:459983	131/692 (19%)
		Cullin_Nedd8	696..756	CDD:463146	24/59 (41%)