Protein Alignment CG11262 and OCA2

DIOPT Version :10

• Sequence 1: NP_648617.2
• Gene: CG11262 / 39471
• FlyBaseID: FBgn0036329
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_016877744.1
• Gene: OCA2 / 4948
• HGNCID: 8101
• Length: 860
• Species: Homo sapiens
• Alignment Length: 705
• Identity: 258/705 - (36%)
• Similarity: 384/705 - (54%)
• Gaps: 61/705 - (8%)

  Fly    46 LDEPETISVGRFIFKIIRIGALLLIWAFFTYILVRN---ATTPD---LTSVVTVLPNETVLRRLS 104
            ||.|.   :...:.|:.|....|.:...|.::::.:   :..||   |..::.:.|.|.....||
Human   167 LDSPH---IRLRLSKLRRCVQWLKVMGLFAFVVLCSILFSLYPDQGKLWQLLALSPLENYSVNLS 228

  Fly   105 VPHDAT--QITLKGPI----DLQLQKHESVIMETPH---VGVRVEWRDSELKTKFWSSDMWIVYL 160
            ...|:|  |:.|.|.:    ..:..:.|.:::|...   :|.|  ||..:..|..|:     |||
Human   229 SHVDSTLLQVDLAGALVASGPSRPGREEHIVVELTQADALGSR--WRRPQQVTHNWT-----VYL 286

  Fly   161 AEQSQAFTKTSKTVQISEVSNAQAVISLESRSEEPVALLMVVSVYPLVTENGVLYAALLLIGFYI 225
            ..:....:..|:|.::.........|....:..:.|.|||.........|..|..|..:|.|.|.
Human   287 NPRRSEHSVMSRTFEVLTRETVSISIRASLQQTQAVPLLMAHQYLRGSVETQVTIATAILAGVYA 351

  Fly   226 LIVFELTDRTFAALMMATTGIAILTALGNRPTLETIISWIDFETLILLLGMMILVAIMSETGVFD 290
            ||:||:..||.||::.:...:|.|..:|:||:|..::.|||||||.||.||||||||.||||.||
Human   352 LIIFEIVHRTLAAMLGSLAALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFD 416

  Fly   291 WMAVLAYRISKGNPWPMLLLLSSITAIMSCMLDNVTMLLLMAPIAIRLCEAMAVQTPLVLIVVVM 355
            :.||.|||:|:|..|.|:::|..|.|::|..|||||.:||..|:.|||||.:.:....|||..|:
Human   417 YCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVI 481

  Fly   356 YSNIGGTLTPVGDPPNVIIATNSEVISAGVDFLDFTIHMLPGVLLAAVAGYAVMYVTM--RK--- 415
            ::||||..|.:||||||||.:|.|:...|:||..||.||..|:.|..:..:.::.:..  ||
Human   482 FTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYN 546

  Fly   416 -------------SLFKLEEQQLELAAERENSRRRSSADITARAEEMRIRQ--PTGRQLLKPAEN 465
                         .:::|..|::..|:..|.:.||.........|.:..|:  ...||:.:..:|
Human   547 KEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLHTFHRQISQEDKN 611

  Fly   466 YFQTLAHLEAHHRIRDKTLLIKCLFTLCFVIIFFLLHS-LPFMHGATLGWVAILAAFLLLILAKM 529
            :...:..|:..|||.|..||.|||..|.|||..|.|:| :|.:| ..|||:|||.|..|||||.:
Human   612 WETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVPGIH-LDLGWIAILGAIWLLILADI 675

  Fly   530 NDIEAILDQVEWSALLFLAALFVLTEAVDKLGFIRWLCDLTVKVIMSVEERYQTTVAILIIIWMS 594
            :|.|.||.:|||:.|||.||||||.||:..|..|.::.:.|..:|..|.|..:...||::::|:|
Human   676 HDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEEQRLIAAIVLVVWVS 740

  Fly   595 AILAAFVGNVPVT-----TMLLRLN---------IELHRNDAISVPLTPLIWALSYGACFGGNGT 645
            |:.::.:.|:|.|     |..||::         :.|..:..:.:|..||::||::|||.|||||
Human   741 ALASSLIDNIPFTATMIDTSYLRIHQLVLKIPVLLNLSHDPEVGLPAPPLMYALAFGACLGGNGT 805

  Fly   646 LIGASANVVAAAIAQQYGYKISFVQFFIYGFPMMLTSIFLATVYLLIAHSLFAWH 700
            |||||||||.|.||:|:||..||::||..|||||:.|..:...|||:||.:..|:
Human   806 LIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCTVGMCYLLVAHVVVGWN 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11262	NP_648617.2	P_permease	220..691	CDD:238536	213/505 (42%)
OCA2	XP_016877744.1	P_permease	346..851	CDD:238536	213/505 (42%)