Protein Alignment CG10749 and MDH2

DIOPT Version :9

• Sequence 1: NP_648616.1
• Gene: CG10749 / 39470
• FlyBaseID: FBgn0036328
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_014515.2
• Gene: MDH2 / 853994
• SGDID: S000005486
• Length: 377
• Species: Saccharomyces cerevisiae
• Alignment Length: 379
• Identity: 144/379 - (37%)
• Similarity: 206/379 - (54%)
• Gaps: 68/379 - (17%)

  Fly    13 NLPPKVQQLGYINRGLKVAVVGSVGGIGQPLSLLLKHNPQIST-----------LSLYDIKN--T 64
            ::.|.::|     ..||:|::|:.|||||.||||||...|...           |:|||:..  .
Yeast     4 SVTPSIEQ-----DSLKIAILGAAGGIGQSLSLLLKAQLQYQLKESNRSVTHIHLALYDVNQEAI 63

  Fly    65 TGVGVDLSHINTRASVCPFEGKNGLKKAMDKADIVVIPAGLPRKPGMKREDLVDVNASVACEVAF 129
            .||..|||||:|..||.......|::..:..|.|||||||:||||||.|:||.:|||.:..::..
Yeast    64 NGVTADLSHIDTPISVSSHSPAGGIENCLHNASIVVIPAGVPRKPGMTRDDLFNVNAGIISQLGD 128

  Fly   130 AASEVC--PGAMLAFITNPINVIVPI-VATILK----AKGTYDPNRLFGVTTLDVVRAQTFVADI 187
            :.:|.|  ....:..|:||:|.:||: |:.|||    ::.:....|:.|||.||:|||.||:.:|
Yeast   129 SIAECCDLSKVFVLVISNPVNSLVPVMVSNILKNHPQSRNSGIERRIMGVTKLDIVRASTFLREI 193

  Fly   188 LNVD---PQKVN----IPVIGGHTGRTILPILSQCDPPFKGTDKEREALIQRIQNAGTEVVNAKD 245
             |::   ..:||    :||||||:|.||:|:.||.:...:..:.:.:.||.|:|..|.|||.||:
Yeast   194 -NIESGLTPRVNSMPDVPVIGGHSGETIIPLFSQSNFLSRLNEDQLKYLIHRVQYGGDEVVKAKN 257

  Fly   246 GLGSATLSMAFA----ATQFVSSLIKGIKGSKDECIVECAYVE------------SD-----VTE 289
            |.||||||||.|    ..||||.|:..|     |.|....||.            :|     |..
Yeast   258 GKGSATLSMAHAGYKCVVQFVSLLLGNI-----EQIHGTYYVPLKDANNFPIAPGADQLLPLVDG 317

  Fly   290 AQFFATPLILGPQGVK--ENTGLPDLDDEERKALNGMLPI----LKESIAKGIK 337
            |.:||.||.:..:||.  :...:..::|.||   |.||||    ||::|.||::
Yeast   318 ADYFAIPLTITTKGVSYVDYDIVNRMNDMER---NQMLPICVSQLKKNIDKGLE 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10749	NP_648616.1	MDH_glyoxysomal_mitochondrial	28..337	CDD:133422	142/362 (39%)
		MDH_euk_gproteo	29..345	CDD:130833	141/363 (39%)
MDH2	NP_014515.2	MDH_euk_gproteo	15..372	CDD:130833	141/363 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S410
OMA	1	1.010	-	-		QHG56560
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11540
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.760