DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10749 and MDH1

DIOPT Version :9

Sequence 1:	NP_648616.1	Gene:	CG10749 / 39470	FlyBaseID:	FBgn0036328	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_012838.1	Gene:	MDH1 / 853777	SGDID:	S000001568	Length:	334	Species:	Saccharomyces cerevisiae

Alignment Length:	313	Identity:	148/313 - (47%)
Similarity:	211/313 - (67%)	Gaps:	8/313 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KVAVVGSVGGIGQPLSLLLKHNPQISTLSLYDIKNTTGVGVDLSHINTRASVCPF--EGKNGLKK 91
            ||.|:|:.||||||||||||.|.:::.|.|||:|...||..|||||.|.:.|..|  |..:||..
Yeast    19 KVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVATDLSHIPTNSVVKGFTPEEPDGLNN 83

  Fly    92 AMDKADIVVIPAGLPRKPGMKREDLVDVNASVACEVAFAASEVCPGAMLAFITNPINVIVPIVAT 156
            |:...|:|:||||:||||||.|:||..:|||:..::|.|.:|..|.|.:..|:||:|..|||||.
Yeast    84 ALKDTDMVLIPAGVPRKPGMTRDDLFAINASIVRDLAAATAESAPNAAILVISNPVNSTVPIVAQ 148

  Fly   157 ILKAKGTYDPNRLFGVTTLDVVRAQTFVADILNVDPQKVNIPVIGGHTGRTILPILSQCDPPFKG 221
            :||.||.|:|.:||||||||.:||..|::::.|.||.:..:.|||||:|.||:|::||.:.....
Yeast   149 VLKNKGVYNPKKLFGVTTLDSIRAARFISEVENTDPTQERVNVIGGHSGITIIPLISQTNHKLMS 213

  Fly   222 TDKEREALIQRIQNAGTEVVNAKDGLGSATLSMAFAATQFVSSLIKGIKGSKDECIVECAYVESD 286
            .||..| ||.|||..|.|||.||:|.||||||||.|..:|.::::.|.||.:|  ::|.::|:|.
Yeast   214 DDKRHE-LIHRIQFGGDEVVKAKNGAGSATLSMAHAGAKFANAVLSGFKGERD--VIEPSFVDSP 275

  Fly   287 VTEA---QFFATPLILGPQGVKENTGLPDLDDEERKALNGMLPILKESIAKGI 336
            :.::   :|||:|:.|||.|:::...:.:|..||.:.|......||::|.||:
Yeast   276 LFKSEGIEFFASPVTLGPDGIEKIHPIGELSSEEEEMLQKCKETLKKNIEKGV 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10749	NP_648616.1	MDH_glyoxysomal_mitochondrial	28..337	CDD:133422	148/313 (47%)
CG10749	NP_648616.1	MDH_euk_gproteo	29..345	CDD:130833	148/313 (47%)
MDH1	NP_012838.1	MDH_glyoxysomal_mitochondrial	18..331	CDD:133422	148/313 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I1005
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	315	1.000	Inparanoid score	I464
Isobase	1	0.950	-	0	Normalized mean entropy	S410
OMA	1	1.010	-	-		QHG56560
OrthoFinder	1	1.000	-	-		FOG0001716
OrthoInspector	1	1.000	-	-		otm46892
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11540
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1106
TreeFam	1	0.960	-	-
	11	10.880