Protein Alignment CG10749 and MDH2

DIOPT Version :10

• Sequence 1: NP_648616.1
• Gene: CG10749 / 39470
• FlyBaseID: FBgn0036328
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_005909.2
• Gene: MDH2 / 4191
• HGNCID: 6971
• Length: 338
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 158/307 - (51%)
• Similarity: 216/307 - (70%)
• Gaps: 2/307 - (0%)

  Fly    29 KVAVVGSVGGIGQPLSLLLKHNPQISTLSLYDIKNTTGVGVDLSHINTRASVCPFEGKNGLKKAM 93
            ||||:|:.||||||||||||::|.:|.|:||||.:|.||..|||||.|:|:|..:.|...|...:
Human    26 KVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCL 90

  Fly    94 DKADIVVIPAGLPRKPGMKREDLVDVNASVACEVAFAASEVCPGAMLAFITNPINVIVPIVATIL 158
            ...|:||||||:||||||.|:||.:.||::...:..|.::.||.||:..|.||:|..:||.|.:.
Human    91 KGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVF 155

  Fly   159 KAKGTYDPNRLFGVTTLDVVRAQTFVADILNVDPQKVNIPVIGGHTGRTILPILSQCDPPFKGTD 223
            |..|.|:||::|||||||:|||.||||::..:||.:||:||||||.|:||:|::|||.|......
Human   156 KKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQ 220

  Fly   224 KEREALIQRIQNAGTEVVNAKDGLGSATLSMAFAATQFVSSLIKGIKGSKDECIVECAYVESDVT 288
            .:..||..|||.||||||.||.|.||||||||:|..:||.||:..:.|.  |.:|||::|:|..|
Human   221 DQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGK--EGVVECSFVKSQET 283

  Fly   289 EAQFFATPLILGPQGVKENTGLPDLDDEERKALNGMLPILKESIAKG 335
            |..:|:|||:||.:|:::|.|:..:...|.|.::..:|.||.||.||
Human   284 ECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKG 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10749	NP_648616.1	MDH_glyoxysomal_mitochondrial	28..337	CDD:133422	158/307 (51%)
MDH2	NP_005909.2	MDH_glyoxysomal_mitochondrial	26..334	CDD:133422	158/307 (51%)