DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10749 and mdh1aa

DIOPT Version :9

Sequence 1:	NP_648616.1	Gene:	CG10749 / 39470	FlyBaseID:	FBgn0036328	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_001303854.1	Gene:	mdh1aa / 399662	ZFINID:	ZDB-GENE-040204-1	Length:	354	Species:	Danio rerio

Alignment Length:	329	Identity:	69/329 - (20%)
Similarity:	120/329 - (36%)	Gaps:	90/329 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GSVGGIGQPLSL-LLKHNPQISTLSLYDIKNTTGVGVDLSH--INTRASVCPFEGKNGLKKAMDK 95
            |.|.|..||:.| ||...|.:..|.        ||.::|..  :.....|.|   .:.::.....
Zfish    27 GDVFGKDQPIILVLLDITPMLPVLD--------GVVMELQDCALPLLREVIP---TDKVEVGFKD 80

  Fly    96 ADIVVIPAGLPRKPGMKREDLVDVNASV------ACEVAFAASEVCPGAMLAFITNPINVIVPIV 154
            .|..::...:|||.||:|:||:..|.::      |.| .:|...|    .:..:.||.|....|.
Zfish    81 LDAAILVGSMPRKEGMERKDLLKANVAIFKTQGEALE-KYAKKTV----KVLVVGNPANTNCLIA 140

  Fly   155 ATILKAKGTYDPNRLFGVTTLDVVRAQTFVADILNVDPQKV-NIPVIGGHT-------------- 204
            :   |:..:........:|.||..||::.||..:.|....| |:.:.|.|:
Zfish   141 S---KSAPSIPKENFSCLTRLDHNRARSQVAMRVGVPSDSVKNVTIWGNHSSTQYPDVHHAIVTR 202

  Fly   205 -GRTILPILSQCDPPFKGTDKEREALIQRIQNAGTEVVNAKDGLGSATLSMAFAATQFVSSLIKG 268
             |:.|....:..|..:...|     .|..:|..|..|:.|:      .||.|.:|.:.:...::.
Zfish   203 NGKEIAAFDAVNDESWLKGD-----FISTVQQRGAAVIKAR------KLSSAMSAAKAICDHMRD 256

  Fly   269 IKGSKDECIVECAYVESDVTEAQFFATP----LILGPQGVKENTGLPD---------LDDEERKA 320
            |                      :|.||    :.:|......:.|:||         :.::..|.
Zfish   257 I----------------------WFGTPDGEWVSMGIYSSGNSYGVPDDLMYSFPVKIKNKSWKV 299

  Fly   321 LNGM 324
            ::|:
Zfish   300 VDGL 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10749	NP_648616.1	MDH_glyoxysomal_mitochondrial	28..337	CDD:133422	69/329 (21%)
CG10749	NP_648616.1	MDH_euk_gproteo	29..345	CDD:130833	69/329 (21%)
mdh1aa	NP_001303854.1	PRK05442	1..326	CDD:235468	69/329 (21%)
		MDH_cytoplasmic_cytosolic	3..328	CDD:133421	69/329 (21%)
		PTS1	352..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810