DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10749 and Mdh1

DIOPT Version :9

Sequence 1:	NP_648616.1	Gene:	CG10749 / 39470	FlyBaseID:	FBgn0036328	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_001303806.1	Gene:	Mdh1 / 24551	RGDID:	3072	Length:	355	Species:	Rattus norvegicus

Alignment Length:	336	Identity:	78/336 - (23%)
Similarity:	128/336 - (38%)	Gaps:	67/336 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LKVAVVGSVGGIGQPLSLLLKHNPQISTLSLYDIKNTTGVGVDLSHINTRASVCPFEG-KNGLKK 91
            ::|.|.|:.|              ||:...||.|.|.:..|.|...|.....:.|..| .:|:..
  Rat     5 IRVLVTGAAG--------------QIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLM 55

  Fly    92 --------------AMDK-------ADIVVIPAGLPRKPGMKREDLVDVNASVACEVAFAASEVC 135
                          |.||       .|:.|:...:||:.||:|:||:..|..:......|..:..
  Rat    56 ELQDCALPLLQDVIATDKEEVAFKDLDVAVLVGSMPRREGMERKDLLKANVKIFKSQGAALEKYA 120

  Fly   136 PGAMLAFIT-NPINVIVPIVATILKAKGTYDPNRLFGVTTLDVVRAQTFVADILNVDPQKVNIPV 199
            ..::...:. ||.|.   ...|..|:..:........:|.||..||::.:|..|.|....|...:
  Rat   121 KKSVKVIVVGNPANT---NCLTASKSAPSIPKENFSCLTRLDHNRAKSQIALKLGVTADDVKNVI 182

  Fly   200 IGGHTGRTILPILSQCDPPFKGTDKE---REAL----------IQRIQNAGTEVVNAKDGLGSAT 251
            |.|:...|..|.::......:|  ||   .|||          |..:|..|..|:.|:      .
  Rat   183 IWGNHSSTQYPDVNHAKVKLQG--KEVGVYEALKDDSWLKGEFITTVQQRGAAVIKAR------K 239

  Fly   252 LSMAFAATQFVSSLIKGIKGSKDECIVECAYVESD-----VTEAQFFATPLILGPQGVKENTGLP 311
            ||.|.:|.:.:|..|:.|.....|.......|.||     |.:...::.|:::..:..|...|||
  Rat   240 LSSAMSAAKAISDHIRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLP 304

  Fly   312 DLDDEERKALN 322
             ::|..|:.::
  Rat   305 -INDFSREKMD 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10749	NP_648616.1	MDH_glyoxysomal_mitochondrial	28..337	CDD:133422	78/336 (23%)
CG10749	NP_648616.1	MDH_euk_gproteo	29..345	CDD:130833	78/335 (23%)
Mdh1	NP_001303806.1	MalateDH-SF1	2..327	CDD:130820	78/336 (23%)
		MDH_cytoplasmic_cytosolic	3..328	CDD:133421	78/336 (23%)
		PTS1	353..355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810