DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10749 and Ldhb

DIOPT Version :9

Sequence 1:	NP_648616.1	Gene:	CG10749 / 39470	FlyBaseID:	FBgn0036328	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_001303251.1	Gene:	Ldhb / 16832	MGIID:	96763	Length:	341	Species:	Mus musculus

Alignment Length:	347	Identity:	79/347 - (22%)
Similarity:	138/347 - (39%)	Gaps:	84/347 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KVAVVGSVGGIGQPLSLLLKHNPQISTLSLYDI--KNTTGVGVDLSHINTRASVCPFEGKNGLKK 91
            |:.||| ||.:|...::.:........|:|.|:  ....|..:||.|           |...|:.
Mouse    23 KITVVG-VGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQH-----------GSLFLQT 75

  Fly    92 AMDKAD----------IVVIPAGLPRKPGMKREDLVDVNASVACEVAFAASEVCPGAMLAFITNP 146
            ....||          |||:.||:.::.|..|.:||..|.:|...:.....:..|...:..::||
Mouse    76 PKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCTIIVVSNP 140

  Fly   147 INVIVPIVATILKAKGTYDPNRLFGV---------TTLDVVRAQTFVADILNVDPQKVNIPVIGG 202
            ::::            ||...:|.|:         ..||..|.:..:|:.|.:.|...:..::|.
Mouse   141 VDIL------------TYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGE 193

  Fly   203 H--------TGRTILPILSQCDPPFKGTDKERE---ALIQRIQNAGTEVVNAKD------GLGSA 250
            |        :|..:..:..|...|..|||.:.|   .:.:.:.::..||:..|.      ||..|
Mouse   194 HGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVDSAYEVIKLKGYTNWAIGLSVA 258

  Fly   251 TL--SMAFAATQF--VSSLIKGIKGSKDECIVECAYVESDVTEAQFFATPLILGPQGVKENTGLP 311
            .|  ||....::.  ||:::||:.|           :|::|    |.:.|.||..:|:.......
Mouse   259 DLIESMLKNLSRIHPVSTMVKGMYG-----------IENEV----FLSLPCILNARGLTSVINQK 308

  Fly   312 DLDDEE---RKALNGMLPILKE 330
            ..|||.   ||:.:.:..|.|:
Mouse   309 LKDDEVAQLRKSADTLWDIQKD 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10749	NP_648616.1	MDH_glyoxysomal_mitochondrial	28..337	CDD:133422	79/347 (23%)
CG10749	NP_648616.1	MDH_euk_gproteo	29..345	CDD:130833	79/347 (23%)
Ldhb	NP_001303251.1	LDH_1	20..330	CDD:133429	78/345 (23%)
		L-LDH-NAD	26..326	CDD:273796	76/338 (22%)
		PTS1	339..341
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810