Protein Alignment CG10749 and MDH1B

DIOPT Version :10

• Sequence 1: NP_648616.1
• Gene: CG10749 / 39470
• FlyBaseID: FBgn0036328
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_001034934.1
• Gene: MDH1B / 130752
• HGNCID: 17836
• Length: 518
• Species: Homo sapiens
• Alignment Length: 324
• Identity: 60/324 - (18%)
• Similarity: 109/324 - (33%)
• Gaps: 68/324 - (20%)

  Fly    28 LKVAVVGSVGGIGQPLSLLLKHNPQISTLSLYDIKNTTGVGVDL-SHINTRASVCPFEGKNGLKK 91
            :.:...|.|.|:...:|:.|..|.|...    .:|:......|| |.:....|:|     ..:::
Human   148 IPILTSGEVFGMHTEISITLFDNKQAEE----HLKSLVVETQDLASPVLRSVSIC-----TKVEE 203

  Fly    92 AMDKADIVVIPAGLPRKPGMKRED--------------LVDVNASVACEVAFAASEVCPGAMLAF 142
            |..:|.::|:......|.....||              |::.||..:..|............:..
Human   204 AFRQAHVIVVLDDSTNKEVFTLEDCLRSRVPLCRLYGYLIEKNAHESVRVIVGGRTFVNLKTVLL 268

  Fly   143 ITNPINVIVPIVATILKAKGTYDPNRLFGVTTLDVVRAQTFVADIL---------NVDPQKVNI- 197
            :.....:...|:|..|..:|     ....:....:..|.:::.|::         .||.:|..:
Human   269 MRYAPRIAHNIIAVALGVEG-----EAKAILARKLKTAPSYIKDVIIWGNISGNNYVDLRKTRVY 328

  Fly   198 ---PVIGG--HTGRTILPILSQCDPPFKGTDKEREALIQRIQNAGTEVVNAKDGLGSATLSMAFA 257
               ..|.|  |..|.:|.::...:    ...:|..|:::.:...|.:.    .|:        .|
Human   329 RYESAIWGPLHYSRPVLNLIFDSE----WVKREFVAILKNLTTTGRQF----GGI--------LA 377

  Fly   258 ATQFVSSLIKGIKGSKDECIVECAYVESDVTEAQFFATPLILGPQGVKENTG----LPDLDDEE 317
            |....::|.....||....||....    ::|.||.....|:....||...|    |.||.|.|
Human   378 AHSIATTLKYWYHGSPPGEIVSLGI----LSEGQFGIPKGIVFSMPVKFENGTWVVLTDLKDVE 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10749	NP_648616.1	MDH_glyoxysomal_mitochondrial	28..337	CDD:133422	60/324 (19%)
MDH1B	NP_001034934.1	MDH_like	9..459	CDD:133431	60/324 (19%)