Protein Alignment CG10748 and MDH2

DIOPT Version :10

• Sequence 1: NP_648615.1
• Gene: CG10748 / 39469
• FlyBaseID: FBgn0036327
• Length: 349
• Species: Drosophila melanogaster
• Sequence 2: NP_005909.2
• Gene: MDH2 / 4191
• HGNCID: 6971
• Length: 338
• Species: Homo sapiens
• Alignment Length: 336
• Identity: 151/336 - (44%)
• Similarity: 215/336 - (63%)
• Gaps: 7/336 - (2%)

  Fly     7 LKSLAKPATWGV-------VVRTLKVAVVGAGGGIGQPLSLLLRRCPGIDELALHDLSEMKGIAT 64
            |.:||:||:..:       .....||||:||.|||||||||||:..|.:..|.|:|::...|:|.
Human     2 LSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAA 66

  Fly    65 DLSHISQTGKVIGFTGEKELESAVSGADVVVVAAGMPRLPGMQRDHLMAANGNVAVKVATAISNA 129
            |||||.....|.|:.|.::|...:.|.||||:.||:||.|||.||.|...|..:...:..|.:..
Human    67 DLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQH 131

  Fly   130 SPRAHLAFITNPVNMIVPAAAEVLMAHGTFDSRRLFGITTLDVVRSKKFIGDSMNISPDDVNIPV 194
            .|.|.:..|.||||..:|..|||...||.::..::||:||||:||:..|:.:...:.|..||:||
Human   132 CPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPV 196

  Fly   195 IGGHAGITILPLISQCQPIYRCDLQEIQNLTHRIQEAGTEVVNAKAGKGSATLSMAYAGATFVNS 259
            ||||||.||:||||||.|.......::..||.||||||||||.||||.||||||||||||.||.|
Human   197 IGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFS 261

  Fly   260 LLRGIAGQDGLIECAFVASKLTDAPFFASPLELGKDGIKRYIPLPQMSDYEKEALEKLLPILRQN 324
            |:..:.|::|::||:||.|:.|:..:|::||.|||.||::.:.:.::|.:|::.:...:|.|:.:
Human   262 LVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKAS 326

  Fly   325 ADEGVNFAKMI 335
            ..:|.:|.|.:
Human   327 IKKGEDFVKTL 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10748	NP_648615.1	MDH_glyoxysomal_mitochondrial	36..332	CDD:133422	134/295 (45%)
MDH2	NP_005909.2	MDH_glyoxysomal_mitochondrial	26..334	CDD:133422	144/307 (47%)