DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10748 and MDH1

DIOPT Version :9

Sequence 1:	NP_648615.1	Gene:	CG10748 / 39469	FlyBaseID:	FBgn0036327	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_001303303.1	Gene:	MDH1 / 4190	HGNCID:	6970	Length:	353	Species:	Homo sapiens

Alignment Length:	356	Identity:	76/356 - (21%)
Similarity:	130/356 - (36%)	Gaps:	77/356 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LKVAVVGAGGGIGQPL-------SLLLRRCPGIDELALHDLSEMKG------------------- 61
            ::|.|.||.|.|...|       |:..:..|.|  |.|.|::.|.|
Human     5 IRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPII--LVLLDITPMMGVLDGVLMELQDCALPLLKD 67

  Fly    62 -IATDLSHISQTGKVIGFTGEKELESAVSGADVVVVAAGMPRLPGMQRDHLMAANGNVAVKVATA 125
             ||||                || :.|....||.::...|||..||:|..|:.||..:......|
Human    68 VIATD----------------KE-DVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAA 115

  Fly   126 ISN-ASPRAHLAFITNPVNMIVPAAAEVLMAHGTFDSRRLFGITTLDVVRSKKFIGDSMNISPDD 189
            :.. |.....:..:.||.|.....|::   :..:........:|.||..|:|..|...:.::.:|
Human   116 LDKYAKKSVKVIVVGNPANTNCLTASK---SAPSIPKENFSCLTRLDHNRAKAQIALKLGVTAND 177

  Fly   190 VNIPVIGGHAGITILPLISQCQ--------PIYRC---DLQEIQNLTHRIQEAGTEVVNAKAGKG 243
            |...:|.|:...|..|.::..:        .:|..   |..........:|:.|..|:  ||.|.
Human   178 VKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVI--KARKL 240

  Fly   244 SATLSMAYAGATFVNSLLRGIAGQDGLIECAFVA-SKLTDAPFFASPLEL-------GKDGIKRY 300
            |:.:|.|.|....|..:..|..      |..||: ..::|...:..|.:|       .|:...::
Human   241 SSAMSAAKAICDHVRDIWFGTP------EGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKF 299

  Fly   301 IPLPQMSDYEKEALEKLLPILRQNADEGVNF 331
            :....::|:.:|.::.....|.:..:....|
Human   300 VEGLPINDFSREKMDLTAKELTEEKESAFEF 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10748	NP_648615.1	MDH_euk_gproteo	36..333	CDD:130833	70/343 (20%)
CG10748	NP_648615.1	MDH_glyoxysomal_mitochondrial	36..332	CDD:133422	70/343 (20%)
MDH1	NP_001303303.1	MalateDH-SF1	2..327	CDD:130820	75/351 (21%)
		MDH_cytoplasmic_cytosolic	3..328	CDD:133421	75/352 (21%)
		PTS1	351..353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810