DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10748 and Mdh1

DIOPT Version :9

Sequence 1:	NP_648615.1	Gene:	CG10748 / 39469	FlyBaseID:	FBgn0036327	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_001303806.1	Gene:	Mdh1 / 24551	RGDID:	3072	Length:	355	Species:	Rattus norvegicus

Alignment Length:	370	Identity:	82/370 - (22%)
Similarity:	139/370 - (37%)	Gaps:	82/370 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LKVAVVGAGGGIGQPL-------SLLLRRCPGIDELALHDLSEMKG------------------- 61
            ::|.|.||.|.|...|       |:..:..|.|  |.|.|::.|.|
  Rat     5 IRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPII--LVLLDITPMMGVLDGVLMELQDCALPLLQD 67

  Fly    62 -IATDLSHISQTGKVIGFTGEKELESAVSGADVVVVAAGMPRLPGMQRDHLMAANGNVAVKVATA 125
             ||||                || |.|....||.|:...|||..||:|..|:.||..:......|
  Rat    68 VIATD----------------KE-EVAFKDLDVAVLVGSMPRREGMERKDLLKANVKIFKSQGAA 115

  Fly   126 ISN-ASPRAHLAFITNPVNMIVPAAAEVLMAHGTFDSRRLFGITTLDVVRSKKFIGDSMNISPDD 189
            :.. |.....:..:.||.|.....|::   :..:........:|.||..|:|..|...:.::.||
  Rat   116 LEKYAKKSVKVIVVGNPANTNCLTASK---SAPSIPKENFSCLTRLDHNRAKSQIALKLGVTADD 177

  Fly   190 VNIPVIGGHAGITILPLISQCQ--------PIYRCDLQEIQNLTHR----IQEAGTEVVNAKAGK 242
            |...:|.|:...|..|.::..:        .:|.. |::...|...    :|:.|..|:.|:
  Rat   178 VKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEA-LKDDSWLKGEFITTVQQRGAAVIKAR--- 238

  Fly   243 GSATLSMAYAGATFVNSLLRGIAGQDGLIECAFVA-SKLTDAPFFASPLEL-------GKDGIKR 299
               .||.|.:.|..::..:|.|  ..|..|..||: ..::|...:..|.:|       .|:...:
  Rat   239 ---KLSSAMSAAKAISDHIRDI--WFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWK 298

  Fly   300 YIPLPQMSDYEKEALEKLLPILRQNADEGVNFAKMILSGQSHSPI 344
            ::....::|:.:|.::.....|.:..:....|   :.|...||.:
  Rat   299 FVEGLPINDFSREKMDLTAKELTEEKETAFEF---LSSAXLHSRV 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10748	NP_648615.1	MDH_euk_gproteo	36..333	CDD:130833	73/344 (21%)
CG10748	NP_648615.1	MDH_glyoxysomal_mitochondrial	36..332	CDD:133422	72/343 (21%)
Mdh1	NP_001303806.1	MalateDH-SF1	2..327	CDD:130820	78/352 (22%)
		MDH_cytoplasmic_cytosolic	3..328	CDD:133421	78/353 (22%)
		PTS1	353..355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810