DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10748 and Ldhb

DIOPT Version :9

Sequence 1:	NP_648615.1	Gene:	CG10748 / 39469	FlyBaseID:	FBgn0036327	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_001303262.1	Gene:	Ldhb / 24534	RGDID:	2997	Length:	341	Species:	Rattus norvegicus

Alignment Length:	287	Identity:	68/287 - (23%)
Similarity:	126/287 - (43%)	Gaps:	53/287 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KSLAKPATWGVVVRTLKVAVVGAGG-GIGQPLSLLLRRCPGIDELALHDLSE--MKGIATDLSHI 69
            |.:|..|.....|...|:.|||.|. |:...:|:|.:..  .|||||.|:.|  :||...||.|.
  Rat     7 KLIAPVADDETAVPNNKITVVGVGQVGMACAISILGKSL--ADELALVDVLEDKLKGEMMDLQHG 69

  Fly    70 S---QTGKVIGFTGEKELESAVSGADVVVVAAGMPRLPGMQRDHLMAANGNVAVKVATAISNASP 131
            |   ||.|::   .:|:. |..:.:.:|||.||:.:..|..|.:|:..|.||...:...|...||
  Rat    70 SLFLQTPKIV---ADKDY-SVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSP 130

  Fly   132 RAHLAFITNPVNMIVPAAAEVLMAHGTFDSRRLFGI---------TTLDVVRSKKFIGDSMNISP 187
            ...:..::|||:::            |:.:.:|.|:         ..||..|.:..:.:.:.|.|
  Rat   131 DCTIIVVSNPVDIL------------TYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHP 183

  Fly   188 DDVNIPVIGGH--------AGITILPL-ISQCQPIYRCD-----LQEIQNLTHRIQEAGTEVVNA 238
            ...:..::|.|        :|:.:..: :.:..|....|     .:|:..:   :.::..||:..
  Rat   184 SSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKM---VVDSAYEVIKL 245

  Fly   239 KAGKGSATLSMAYAGATFVNSLLRGIA 265
               ||....::..:.|..:.|:|:.::
  Rat   246 ---KGYTNWAIGLSVADLIESMLKNLS 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10748	NP_648615.1	MDH_euk_gproteo	36..333	CDD:130833	58/258 (22%)
CG10748	NP_648615.1	MDH_glyoxysomal_mitochondrial	36..332	CDD:133422	58/258 (22%)
Ldhb	NP_001303262.1	PLN02602	4..332	CDD:178212	68/287 (24%)
		LDH_1	20..330	CDD:133429	64/274 (23%)
		PTS1	339..341
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810