DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10748 and Ldhb

DIOPT Version :9

Sequence 1:	NP_648615.1	Gene:	CG10748 / 39469	FlyBaseID:	FBgn0036327	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_001303251.1	Gene:	Ldhb / 16832	MGIID:	96763	Length:	341	Species:	Mus musculus

Alignment Length:	368	Identity:	81/368 - (22%)
Similarity:	149/368 - (40%)	Gaps:	87/368 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KSLAKPATWGVVVRTLKVAVVGAGG-GIGQPLSLLLRRCPGIDELALHDLSE--MKGIATDLSHI 69
            |.:|..|.....|...|:.|||.|. |:...:|:|.:..  .|||||.|:.|  :||...||.|.
Mouse     7 KLIASVADDEAAVPNNKITVVGVGQVGMACAISILGKSL--ADELALVDVLEDKLKGEMMDLQHG 69

  Fly    70 S---QTGKVIGFTGEKELESAVSGADVVVVAAGMPRLPGMQRDHLMAANGNVAVKVATAISNASP 131
            |   ||.|::   .:|:. |..:.:.:|||.||:.:..|..|.:|:..|.||...:...|...||
Mouse    70 SLFLQTPKIV---ADKDY-SVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSP 130

  Fly   132 RAHLAFITNPVNMIVPAAAEVLMAHGTFDSRRLFGI---------TTLDVVRSKKFIGDSMNISP 187
            ...:..::|||:::            |:.:.:|.|:         ..||..|.:..:.:.:.|.|
Mouse   131 DCTIIVVSNPVDIL------------TYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHP 183

  Fly   188 DDVNIPVIGGH--------AGITILPL-ISQCQPIYRCD-----LQEIQNLTHRIQEAGTEVVNA 238
            ...:..::|.|        :|:.:..: :.:..|....|     .:|:..:   :.::..||:..
Mouse   184 SSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKM---VVDSAYEVIKL 245

  Fly   239 KAGKGSATLSMAYAGATFVNSLLRGIA----------GQDGLIECAFVASKLTDAPFFASPLELG 293
               ||....::..:.|..:.|:|:.::          |..|          :.:..|.:.|..|.
Mouse   246 ---KGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYG----------IENEVFLSLPCILN 297

  Fly   294 KDGIKRYI-------PLPQMS-------DYEKEALEKLLPILR 322
            ..|:...|       .:.|:.       |.:|:..:..||:.|
Mouse   298 ARGLTSVINQKLKDDEVAQLRKSADTLWDIQKDLKDLXLPVSR 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10748	NP_648615.1	MDH_euk_gproteo	36..333	CDD:130833	71/339 (21%)
CG10748	NP_648615.1	MDH_glyoxysomal_mitochondrial	36..332	CDD:133422	71/339 (21%)
Ldhb	NP_001303251.1	LDH_1	20..330	CDD:133429	73/343 (21%)
		L-LDH-NAD	26..326	CDD:273796	71/333 (21%)
		PTS1	339..341		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810