Protein Alignment CG10748 and LDHAL6A

DIOPT Version :10

• Sequence 1: NP_648615.1
• Gene: CG10748 / 39469
• FlyBaseID: FBgn0036327
• Length: 349
• Species: Drosophila melanogaster
• Sequence 2: XP_011518224.2
• Gene: LDHAL6A / 160287
• HGNCID: 28335
• Length: 399
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 80/339 - (23%)
• Similarity: 149/339 - (43%)
• Gaps: 70/339 - (20%)

  Fly    24 KVAVVGAGG-GIGQPLSLLLRRCPGI-DELALHDLSE--MKGIATDLSHISQTGKVIGFTGEKEL 84
            |:::||.|. |:...:|:||:   |: |||.|.|:.|  :||...||.|.|...|:......|:.
Human    71 KISIVGTGSVGVACAISILLK---GLSDELVLVDVDEGKLKGETMDLQHGSPFMKMPNIVSSKDY 132

  Fly    85 ESAVSGADVVVVAAGMPRLPGMQRDHLMAANGNVAVKVATAISNASPRAHLAFITNPV------- 142
             ...:.:::|::.||..:..|..|..|:..|.::...:...|:..||...|..:|||.
Human   133 -LVTANSNLVIITAGARQKKGETRLDLVQRNVSIFKLMIPNITQYSPHCKLLIVTNPALCMRKLK 196

  Fly   143 ---NMIVPAAAEVLMAHGTFDSRRLFGI---------TTLDVVRSKKFIGDSMNISPDDVNIPVI 195
               .:::..:.::|    |:.:.:|.|.         ..||..|.:.|||..:.|..:..:..::
Human   197 DISTILLSISVDIL----TYVAWKLSGFPKNRVIGSGCNLDSARFRYFIGQRLGIHSESCHGLIL 257

  Fly   196 GGH--------AGITI--LPLISQCQPIYRCDL--QEIQNLTHRIQEAGTEVVNAKAGKGSATLS 248
            |.|        :|:.|  :|| ....|....|.  ::.:|:..::..:|.|:|..| |..|..:|
Human   258 GEHGDSSVPVWSGVNIAGVPL-KDLNPDIGTDKDPEQWENVHKKVISSGYEMVKMK-GYTSWGIS 320

  Fly   249 MAYAGATF-----------VNSLLRGIAGQDGLIECAFVASKLTDAPFFASPLELGKDGIKRYIP 302
            ::.|..|.           |::|.:|:.|             :.:..|.:.|..||::||...|.
Human   321 LSVADLTESILKNLRRVHPVSTLSKGLYG-------------INEDIFLSVPCILGENGITDLIK 372

  Fly   303 LPQMSDYEKEALEK 316
            : :::..|:..|:|
Human   373 V-KLTLEEEACLQK 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10748	NP_648615.1	MDH_glyoxysomal_mitochondrial	36..332	CDD:133422	75/326 (23%)
LDHAL6A	XP_011518224.2	LDH_1	68..396	CDD:133429	80/339 (24%)