Protein Alignment CG10748 and MDH1B

DIOPT Version :9

• Sequence 1: NP_648615.1
• Gene: CG10748 / 39469
• FlyBaseID: FBgn0036327
• Length: 349
• Species: Drosophila melanogaster
• Sequence 2: NP_001034934.1
• Gene: MDH1B / 130752
• HGNCID: 17836
• Length: 518
• Species: Homo sapiens
• Alignment Length: 248
• Identity: 49/248 - (19%)
• Similarity: 85/248 - (34%)
• Gaps: 52/248 - (20%)

  Fly    81 EKELESAVSGADVVVVAAGMPR----LPGMQRDHLMAANGNVAVKVATAISNASPRAHLAF---- 137
            |:.|::.::...|.:.:|..|.    :|.:....:...:..:::   |...|.....||..
Human   122 EEALKTCINPLQVWITSASAPACYNLIPILTSGEVFGMHTEISI---TLFDNKQAEEHLKSLVVE 183

  Fly   138 ---ITNPVNMIVPAAAEVLMAHGTFDSRRLFGITTLDVVRSKKFIGDSMNISPDDVNIPVIGGHA 199
               :.:||...|....:|..|.     |:...|..||                |..|..|
Human   184 TQDLASPVLRSVSICTKVEEAF-----RQAHVIVVLD----------------DSTNKEV----- 222

  Fly   200 GITILPLISQCQPIYRCDLQEIQNLTH---RIQEAGTEVVNAKAGKGSATLSMAYAGATFVNSLL 261
             .|:...:....|:.|.....|:...|   |:...|...||.|     ..|.|.|| ....::::
Human   223 -FTLEDCLRSRVPLCRLYGYLIEKNAHESVRVIVGGRTFVNLK-----TVLLMRYA-PRIAHNII 280

  Fly   262 RGIAGQDGLIECAFVASKLTDAPFFASPLEL-GKDGIKRYIPLPQMSDYEKEA 313
            ....|.:|..: |.:|.||..||.:...:.: |......|:.|.:...|..|:
Human   281 AVALGVEGEAK-AILARKLKTAPSYIKDVIIWGNISGNNYVDLRKTRVYRYES 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10748	NP_648615.1	MDH_euk_gproteo	36..333	CDD:130833	49/248 (20%)
		MDH_glyoxysomal_mitochondrial	36..332	CDD:133422	49/248 (20%)
MDH1B	NP_001034934.1	MDH_like	9..459	CDD:133431	49/248 (20%)
		MalateDH-SF1	131..457	CDD:130820	47/239 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810