DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14120 and EXOG

DIOPT Version :9

Sequence 1:	NP_648610.1	Gene:	CG14120 / 39463	FlyBaseID:	FBgn0036321	Length:	1371	Species:	Drosophila melanogaster
Sequence 2:	NP_005098.2	Gene:	EXOG / 9941	HGNCID:	3347	Length:	368	Species:	Homo sapiens

Alignment Length:	374	Identity:	90/374 - (24%)
Similarity:	136/374 - (36%)	Gaps:	121/374 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 SGKDCNGGTD---LVQVGFEVEDGGFLQSYELCHDAEAEATRYVHHVLYPSSYDYQHGVARPNFL 202
            :||..:|..:   |.|.||.:              ...||..|.:|.|   |||....|.|
Human    49 TGKQPDGSAEKAVLEQFGFPL--------------TGTEARCYTNHAL---SYDQAKRVPR---- 92

  Fly   203 ELDFYGGRDVNTKYTQVQQNITISNILGLDAS-------------PYFN-FSDDRI---LSRGHM 250
                           .|.::|:.|.|:| ||.             |.|: |::|.:   .|||||
Human    93 ---------------WVLEHISKSKIMG-DADRKHCKFKPDPNIPPTFSAFNEDYVGSGWSRGHM 141

  Fly   251 I-AKTDQIFGAAQHTTFLFINVAPQWQTFNGGNWEKVETSVRKFVADRNLTTDCYTGTWGVS--- 311
            . |..::....|...||...|:.||....|.|.|.::|...|:.       |:.:...|.||
Human   142 APAGNNKFSSKAMAETFYLSNIVPQDFDNNSGYWNRIEMYCREL-------TERFEDVWVVSGPL 199

  Fly   312 TLPDVDGIEREL--YLDFDENNNGLIPVPKIYFRVVIDR---VTREGIVL---------IGINNP 362
            |||...|..:::  |....|:|   :.||...::|::.|   |:.|.:.|         ||. .|
Human   200 TLPQTRGDGKKIVSYQVIGEDN---VAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIGF-QP 260

  Fly   363 YLTLEQIQKDYILCQDIGHQLSWLTWYKE-DLHEGYSYACSVE-----DFIEVVKDLPLEDLH-T 420
            .||..|:.     .||: .:||.|.::.. |........|||:     ||.|....|....:. .
Human   261 QLTEFQVS-----LQDL-EKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEFTLYLSTRKIEGA 319

  Fly   421 NGILGLDDV------TTVEP----------------STTESSTTTEEPS 447
            ..:|.|:.:      ..:||                :..:|.|...:||
Human   320 RSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEELKAKEQSGTQIRKPS 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14120	NP_648610.1	NUC	164..416	CDD:238043	75/292 (26%)
		NUC	718..967	CDD:294067
		NUC	1111..1359	CDD:238043
EXOG	NP_005098.2	NUC	77..286	CDD:214683	65/248 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148106
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940