DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ent3 and FUN26

DIOPT Version :9

Sequence 1:	NP_001287052.1	Gene:	Ent3 / 39461	FlyBaseID:	FBgn0036319	Length:	668	Species:	Drosophila melanogaster
Sequence 2:	NP_009380.1	Gene:	FUN26 / 851211	SGDID:	S000000020	Length:	517	Species:	Saccharomyces cerevisiae

Alignment Length:	576	Identity:	130/576 - (22%)
Similarity:	224/576 - (38%)	Gaps:	168/576 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SGRSRSSHSTTGSGLRRPGSMDSPEFDNRAPKDQRHSV----------------YLALLAAGIGF 66
            ||....|.:...|         ..|.||.:.::|..|.                |:...|.|||.
Yeast    33 SGEEHESENNEHS---------DEEGDNYSEREQSVSTEPLDTLPLRKKLKNLSYITFFAIGIGL 88

  Fly    67 VLPYNSFIIAADYWQARFPGRPVALDMSM-----TYIFVAFGTV--LMNNIVLSVAPFQ--SRVL 122
            :.|:|..:.|:.|::     ..:..|.|:     |...::|.|:  ::.||.|:...::  .||:
Yeast    89 LWPWNCILSASQYFK-----HDIFKDTSIWAKIFTSSMMSFSTISSMLFNIYLAKRQYKYSRRVI 148

  Fly   123 FGY---MISFTTLIFVAVCEV---AWHMFATNTAYLVNMSAVALTAIGCTVQQSSFYGFASMLPK 181
            .|.   :|.||.:.|..:...   .|..|      :..|..|.::::|..:.|:.....|::...
Yeast   149 NGLVWEIIVFTVMCFFTILHFLLPKWFNF------MFIMMLVVISSMGTAMTQNGIMAIANVFGS 207

  Fly   182 QYTQAVMAGESIAGFLVSSNRVVTKL-LINNDRVST----VIFFLTSTLYILFSYLLHVATINSP 241
            :|:|.||.|:::||.|.|  .|:..| .|.|..|||    :::|.|:||         |.||  .
Yeast   208 EYSQGVMVGQAVAGVLPS--LVLFALAFIENSSVSTTGGILLYFFTTTL---------VVTI--C 259

  Fly   242 FVRFHVEACSKIVLRPDEQEIDGVPSSTRYGVLSMDGTHTTTTSVGPPGTGNTLSFSNPVYELSN 306
            .|.|.|   |||..:.:|.             .:::..|.|...:|                  :
Yeast   260 VVMFSV---SKISRKVNEN-------------WNVEDGHITDVLLG------------------S 290

  Fly   307 PTAGESSIEALGQLPELPATPPAQEPTTPTTVAFKVEHVITPRRCRPSKLGDIREGFVTRWRVA- 370
            ..:.|..|..:|::.::.                ..:|    ||...:: .|..||...:.:|.
Yeast   291 LRSNEEEIRIVGRIDQME----------------DEDH----RRTNGTR-DDNDEGEELQLKVPF 334

  Fly   371 QVIYPHMVCIALA----YCVTLSLYPGIEVEVQSCAL----RSWMPVLLMFCFNTSDVVGKILAA 427
            :|::..:..:.|:    :.||| ::|..........|    ..::| |:...:|..|:.|:::|.
Yeast   335 EVLFAKLKYLVLSIFTTFVVTL-VFPVFASATYVTGLPLSNAQYIP-LIFTLWNLGDLYGRVIAD 397

  Fly   428 SP----YPWSRRQLILLSGLRIVLVPLLLLCCAPRQRPVISGE--------------TAPFVFTI 474
            .|    ..::.|:..:.|.||:..:||.|:..|.....  ||:              ...|:|
Yeast   398 WPMFRDQKFTPRKTFIYSLLRVAAIPLFLMFTAITSSS--SGDEEHNGSVIVDLCYMLLQFLF-- 458

  Fly   475 ALGITNGLAGSLPMMLAPAKVPGTL-----KEVTGNIMTLSYNVGLTVGSLIGYVF 525
              |:|||...|:..|    |||..|     ||..|....:..:.||.:||:|.|||
Yeast   459 --GVTNGHVISMSFM----KVPEQLDNDDEKEAAGGFTNIFVSTGLALGSIISYVF 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ent3	NP_001287052.1	Nucleoside_tran	60..529	CDD:301621	120/518 (23%)
FUN26	NP_009380.1	2a57	81..514	CDD:273352	120/519 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343787
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1479
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53699
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750