DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ent3 and Slc29a1

DIOPT Version :9

Sequence 1:	NP_001287052.1	Gene:	Ent3 / 39461	FlyBaseID:	FBgn0036319	Length:	668	Species:	Drosophila melanogaster
Sequence 2:	NP_113872.1	Gene:	Slc29a1 / 63997	RGDID:	61899	Length:	457	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	117/541 - (21%)
Similarity:	201/541 - (37%)	Gaps:	149/541 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PKDQRHSVYLALLAAGIGFVLPYNSFIIAADYWQARF----------------------PGRPVA 90
            |:|:..:|:|.....|:|.:||:|.||.|..|:.:|.                      |...:.
  Rat     7 PQDRYKAVWLIFFVLGLGTLLPWNFFITATQYFTSRLNTSQNISLVTNQSCESTEALADPSVSLP 71

  Fly    91 LDMSMTYIFVAFGTVLMNNIVLSVAPF-----------------QSRVLFGYMISFTTLIFVAVC 138
            ...|::.||        ||::...|..                 ||..:.|.:::...:..|...
  Rat    72 ARSSLSAIF--------NNVMTLCAMLPLLIFTCLNSFLHQKVSQSLRILGSLLAILLVFLVTAT 128

  Fly   139 EVAWHMFATNTAYLVNMSAVALTAIGCTVQQSSFYGFASMLPKQYTQAVMAGESIAGFLVSSNRV 203
            .|...|.|.:...:..:..|.:.:.| .:.|:|.:|.|.:||..||..:|:|:.:|||..|...:
  Rat   129 LVKVQMDALSFFIITMIKIVLINSFG-AILQASLFGLAGVLPANYTAPIMSGQGLAGFFTSVAMI 192

  Fly   204 VTKLLINNDRVSTVIF--FLTSTLYILFSYLLHVATINSPFVRFHVEACSKIVLRPDEQEIDGVP 266
            ..  :.:..::|...|  |:|:...::.:.|.::|.   |::.|:.......:..|.|||
  Rat   193 CA--VASGSKLSESAFGYFITACAVVILAILCYLAL---PWMEFYRHYLQLNLAGPAEQE----- 247

  Fly   267 SSTRYGVLSMDGTHTTTTSVGPPGTGNTLSFSNPVYELSNPTAG--ESSIEALGQLPELPATPPA 329
              |:..::|                           |...|..|  ||.:.....||
  Rat   248 --TKLDLIS---------------------------EGEEPRGGREESGVPGPNSLP-------- 275

  Fly   330 QEPTTPTTVAFKVEHVITPRRCRPSKLGDIREGFVTRWRVAQVIYPHMVCIALAYC----VTLSL 390
                                              ..|.:..:.|...:..:||:.|    ||:.|
  Rat   276 ----------------------------------ANRNQSIKAILKSIWVLALSVCFIFTVTIGL 306

  Fly   391 YPGIEVEVQS--CALRSW-----MPVLLMFCFNTSDVVGKILAA-SPYP-WSRRQLILLSGLRIV 446
            :|.:..||:|  .....|     :||.....||..|.:|:.|.| ..:| ...|.|.:|...|:|
  Rat   307 FPAVTAEVESSIAGTSPWKNCYFIPVACFLNFNVFDWLGRSLTAICMWPGQDSRWLPVLVACRVV 371

  Fly   447 LVPLLLLCCAPRQR--PVISGETAPFV-FTIALGITNGLAGSLPMMLAPAKVPGTLKEVTGNIMT 508
            .:|||:||...:..  |.:......|: |..|...:||...||.|...|.||.....|..||||:
  Rat   372 FIPLLMLCNVKQHHYLPSLFKHDVWFITFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGNIMS 436

  Fly   509 LSYNVGLTVGSLIGYVFESML 529
            ....:||.:|:::.::..:::
  Rat   437 FFLCLGLALGAVLSFLLRALV 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ent3	NP_001287052.1	Nucleoside_tran	60..529	CDD:301621	113/527 (21%)
Slc29a1	NP_113872.1	2a57	18..457	CDD:273352	113/528 (21%)
Slc29a1	NP_113872.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..275		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1479
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53699
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820