DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ent3 and slc29a4a

DIOPT Version :9

Sequence 1:	NP_001287052.1	Gene:	Ent3 / 39461	FlyBaseID:	FBgn0036319	Length:	668	Species:	Drosophila melanogaster
Sequence 2:	NP_001349539.1	Gene:	slc29a4a / 559668	ZFINID:	ZDB-GENE-070112-1932	Length:	521	Species:	Danio rerio

Alignment Length:	509	Identity:	181/509 - (35%)
Similarity:	278/509 - (54%)	Gaps:	59/509 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SMDSPEFDNRAPKDQRHSVYLALLAAGIGFVLPYNSFIIAADYWQARFPGRPVALDMSMTYIFVA 101
            ::..|.|:...|.|:.|.:|.|:|.||:||:|||||||...||...:|.|..:..||.:|||.||
Zfish    50 ALSEPAFEEAVPDDRYHGIYFAMLLAGVGFLLPYNSFITDVDYLHHKFEGTSIVFDMGLTYILVA 114

  Fly   102 FGTVLMNNIVLSVAPFQSRVLFGYMISFTTLIFVAVCEVAWHMFATNTAYLVNMSAVALTAIGCT 166
            ...|::||:::.:....:|:..||:.:...|:||.:.:|....|....||::|:.::...|.|||
Zfish   115 LVAVILNNVLVEMLSLHTRITVGYLFALGPLLFVTIFDVWLERFTIKQAYVINLMSMGTVAFGCT 179

  Fly   167 VQQSSFYGFASMLPKQYTQAVMAGESIAGFLVSSNRVVTKLLINNDRVSTVIFFLTSTLYILFSY 231
            ||||||||:..||||:|||.||.|||.||.::|.:|:.|||||.::|.:|:|||:.|...:|..:
Zfish   180 VQQSSFYGYMGMLPKRYTQGVMTGESTAGVIISLSRIFTKLLIKDERKNTIIFFVISICMVLVCF 244

  Fly   232 LLHVATINSPFVRFHVEACSKIVLRPDEQEIDGVPSSTRYGVLSMDGTHTTTTSVGPPGTGNTLS 296
            :||:....:.||:::    :.:..|......|....:::|.|     .|...|.....|.|
Zfish   245 ILHLLVRRTRFVQYY----TSLARRGLSHAKDHSQHASQYQV-----HHDVITEEVRFGNG---- 296

  Fly   297 FSNPVYELSNPTAGESSIEALGQLPELPATPPAQEPTTP-----TTVAFKVEHVITPRRCRPSKL 356
                               |:|       ..||::....     |.|.|.|     |:.......
Zfish   297 -------------------AVG-------CSPAEDGCADFAGGNTYVRFDV-----PKPKMKRSW 330

  Fly   357 GDIREGFVTRWRVAQVIYPHMVCIALAYCVTLSLYPGIEVEVQSCALRSWMPVLLMFCFNTSDVV 421
            ..:::..:.|:.||:||:.:|:.||:.|.:||.|:||:|.|:::..|..|:|:|:|..||.||.|
Zfish   331 PGVKDMILHRYVVARVIWTYMLSIAVTYFITLCLFPGLESEIKNATLGEWLPILIMAIFNISDFV 395

  Fly   422 GKILAASPYPWSRRQLILLSGLRIVLVPLLLLCCAPRQRPVISGETAPFVFTIALGITNGLAGSL 486
            ||||||.||.|:..:|:..|.:|:|.:||.::|..|.|.|:.|....|.:|::.:|||||..||:
Zfish   396 GKILAAVPYEWNGTRLLFFSCVRVVFIPLFIMCVYPAQMPMFSHPAWPCIFSLFMGITNGYFGSV 460

  Fly   487 PMMLAPAKVPGTLKEVTGNIMTLSYNVGLTVGSLIGYV----------FESMLG 530
            ||:.|..||....:|:.|||||:||..||.:||::.|.          |.|..|
Zfish   461 PMIHAAGKVAPEQRELAGNIMTVSYMSGLMLGSVVAYAAYSFTASGSSFHSQTG 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ent3	NP_001287052.1	Nucleoside_tran	60..529	CDD:301621	173/483 (36%)
slc29a4a	NP_001349539.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
slc29a4a	NP_001349539.1	Nucleoside_tran	73..498	CDD:326577	170/468 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580583
Domainoid	1	1.000	105	1.000	Domainoid score	I6579
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71345
Inparanoid	1	1.050	330	1.000	Inparanoid score	I2432
OMA	1	1.010	-	-		QHG53699
OrthoDB	1	1.010	-	-		D196304at33208
OrthoFinder	1	1.000	-	-		FOG0006908
OrthoInspector	1	1.000	-	-		otm25998
orthoMCL	1	0.900	-	-		OOG6_104430
Panther	1	1.100	-	-	LDO	PTHR10332
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5657
SonicParanoid	1	1.000	-	-		X3859
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.900