DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ent3 and Slc29a3

DIOPT Version :9

Sequence 1:	NP_001287052.1	Gene:	Ent3 / 39461	FlyBaseID:	FBgn0036319	Length:	668	Species:	Drosophila melanogaster
Sequence 2:	NP_853670.2	Gene:	Slc29a3 / 353307	RGDID:	727811	Length:	475	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	131/552 - (23%)
Similarity:	209/552 - (37%)	Gaps:	162/552 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LRRPGSMDSPEFDNRAPKDQRHSVYLALLAAGIGFVLPYNSFIIAADYW-----------QARFP 85
            |.:|  :|.|....:.|:|:.:..|:.....|||.:||:|.|:.|.:||           ..:.|
  Rat    32 LGKP--LDYPAPGLQRPEDRFNGAYIIFFCLGIGGLLPWNFFVTAKEYWAFKLRNCSSPASGKDP 94

  Fly    86 GRPVALDMSMTYIFVAFGTV-----------LMNNIVLSVAPFQSRVLFGYMISFTTLIFVAVC- 138
            .....|:...:|:.|| .||           |:|.|.:.|     |||....:|....:.:||.
  Rat    95 EDADILNYFESYLAVA-STVPSLLFLVANFLLVNRIRVHV-----RVLASLSVSLAIFVVMAVLV 153

  Fly   139 ---EVAWHMFATNTAYLVNMSAVALTAIGCTVQQSSFYGFASMLPKQYTQAVMAGESIAGFLVSS 200
               ..:|    |...:.:.|:.:|:.:...|:..||.||.....|.:..||:::|.::.| .||:
  Rat   154 RVDTSSW----TRGFFSIAMACMAIISSSSTIFNSSVYGLTGSFPMRNAQALISGGAMGG-TVSA 213

  Fly   201 NRVVTKLLINND-RVSTVIFFLTST--------LYILFSYLLHVATINSPFVRFHVEACSKIVLR 256
            ...:..|..::| |.|.:.||||:.        ||:|...|.:......|.|..||
  Rat   214 VASLVDLAASSDVRDSALAFFLTAAVFLGLCVGLYLLLPQLEYARYYMRPVVPIHV--------- 269

  Fly   257 PDEQEIDGVPSSTRYGVLSMDGTHTTTTSVGPPGTGNTLSFSNPVYELSNPTAGESSIEALGQLP 321
                                                    ||:           |.|
  Rat   270 ----------------------------------------FSS-----------EDS-------- 275

  Fly   322 ELPATPPAQEPTTPTTVAFKVEHVITPRRCRPSKLGDIRE-----GFVTRWRVAQVIYPHMVCIA 381
                 ||...|:| ::||.....|.||      .||.|.:     ||               |..
  Rat   276 -----PPRDAPST-SSVAPASRAVHTP------PLGPILKKTAGLGF---------------CAV 313

  Fly   382 LAYCVTLSLYPGIEVEVQSC--------ALRSWMPVLLMFCFNTSDVVGK-ILAASPYPWSRRQL 437
            ..|.:|..::|.|...:|..        ..:.::|:.:...||.:|:.|: :.|....|..|.:|
  Rat   314 FLYFITALIFPAISTNIQPMHKGTGSPWTSKFYVPLTVFLLFNFADLCGRQVTAWIQVPGPRSKL 378

  Fly   438 I-LLSGLRIVLVPLLLLC-CAPRQR---PVISGETAPFVFTIALGITNGLAGSLPMMLAPAKVPG 497
            : :|:..|:.||||.||| ..||..   .:...:..|.:||..||::||...:|.:|..|..||.
  Rat   379 LPILAVSRVCLVPLFLLCNYQPRSHLTLVLFQSDIYPILFTCLLGLSNGYLSTLVLMYGPKIVPR 443

  Fly   498 TLKEVTGNIMTLSYNVGLTVGSLIGYVFESML 529
            .|.|.|..:|....::||.:||....:.|..:
  Rat   444 ELAEATSVVMLFYMSLGLMLGSACAALLEHFI 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ent3	NP_001287052.1	Nucleoside_tran	60..529	CDD:301621	124/522 (24%)
Slc29a3	NP_853670.2	Nucleoside_tran	57..475	CDD:301621	124/523 (24%)
Slc29a3	NP_853670.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..291		8/43 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1479
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53699
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820