DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10948 and enox2

DIOPT Version :9

Sequence 1:	NP_729844.1	Gene:	CG10948 / 39459	FlyBaseID:	FBgn0036317	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_005173205.1	Gene:	enox2 / 566327	ZFINID:	ZDB-GENE-140106-157	Length:	685	Species:	Danio rerio

Alignment Length:	787	Identity:	268/787 - (34%)
Similarity:	394/787 - (50%)	Gaps:	210/787 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LENENEHSADVSSSTMHKEPKLQ--------ATSNSLTLPDSTQLYLNGLVHTPPGYLYFPATQA 123
            |||..|      :|...|.|.|.        ..||||.:|          :..|..:
Zfish    43 LENGTE------NSKKRKRPNLPPEGLRNIGMDSNSLAMP----------ISDPNAW-------- 83

  Fly   124 GGATAPGN----PSSAAGGSTPAASANSTANAQMLM---DPTAMMAAAMQQMQQMHYAAAAAAGM 181
              |||..|    |.|..|              |.:|   ||:..|...:..|..|.
Zfish    84 --ATAMNNLGMAPMSMTG--------------QPIMSDFDPSLGMMTGIAPMNPMM--------- 123

  Fly   182 TTETGAGLEATLNADGVTPAG-------LKEVIKTKNCILFPPNPNAPPPTIRERPPGCRTVFVG 239
                 .||       |:.|..       :||:|..|:|.|||||||.|||..|||||||:|||||
Zfish   124 -----PGL-------GIVPPPVSQDMPIVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVG 176

  Fly   240 GLPENITEEVIREIFESCGEITTLRMSKKNFCHIRYRQEGAIDRAIYLSGYRLRISALNEPPNFG 304
            |||||.||::|.|:||.||.|..:|.|||||||||:.:|..:|:|::|||||:|:.:..:..:.|
Zfish   177 GLPENATEQLIVEVFEQCGGIIAIRKSKKNFCHIRFAEEHTVDKALFLSGYRIRLGSSTDKKDTG 241

  Fly   305 RLHVDYAQARDDQYDYECRQRQHQREQRHRERMSMDRMRSQSPPPIPHYTDHEATTVAEHLRTNE 369
            |||||:||||||.|::|||||...||:|||.|:..||:|..|||||.||::||.:.:.|.|:.:.
Zfish   242 RLHVDFAQARDDLYEWECRQRMLAREERHRRRIEEDRLRPPSPPPIVHYSEHECSQLGEKLKDDS 306

  Fly   370 TFVKAIQTITAWLERGDCTKRNANVFYSMIQSTHAHVRRLHADKLQLEEDLKKARDSYRNQMGTM 434
            .|.:|::.:..|:|||:..:||||.|||||||:::|:|||..:|...|:::::|:|.::|.:..:
Zfish   307 KFPEAVRVLLTWVERGEVNRRNANNFYSMIQSSNSHIRRLMNEKAAHEKEMEEAKDKFKNALSGI 371

  Fly   435 STQFTQIEKVFNAASHKKVWDHFTKAQRKNIDQWKKLATELRTVQ------ITDDDEMEISDDE- 492
            ..||.||..||:|:|.:|.||||:||||||:|.|:|.|.|:|.:.      |..::|||:|||:
Zfish   372 LVQFEQIVSVFHASSKQKAWDHFSKAQRKNLDMWRKQAEEIRNIHNEELMGIRREEEMEMSDDDM 436

  Fly   493 ------RDYDRRGHSAKRIRYDSDGLKDENDSLRCQLEAIRHEMTL----------ERSDY-VQR 540
                  :|.|..|..|:     .:.||:|||||||||:|.|:|:.|          :||:. ..|
Zfish   437 EDVPESKDLDDSGPLAQ-----VEALKEENDSLRCQLDAYRNEVELLKQEQGKAQPQRSEEDATR 496

  Fly   541 EKQIKVLQETIRNMQTQLLQTKLREQKDNKTIEQLERNLKDAGIKQLLLKTKIKETVDKLRDKEA 605
            ::|:..||:.::.||.|||  ||||....:.:| ||:|.::        |.:::..:..|:|
Zfish   497 QQQLSFLQQALQGMQKQLL--KLREDLKQREME-LEKNSEE--------KQQLESQIQTLKD--- 547

  Fly   606 NSAGASNASNASNLDYSSGDSCSREGTEIIRPQAEPEIIDIDKVDDDVRIIEHQSGVVEIHEIED 670
                                          |.||.|              ..|..      .:|.
Zfish   548 ------------------------------RIQAFP--------------TSHAL------PLET 562

  Fly   671 DEKQEPAKDSTKSKANESIMENVSKSNHEETINKSSKEQIP------TVAAEEVTFKSLVLSEAK 729
            .|:::...|.:.:.|:|:....|...:.|       ||.:|      .|.:|.         ||.
Zfish   563 AEREDRGGDESANHASEAATTAVVSCSQE-------KENLPEKGPPSPVKSER---------EAL 611

  Fly   730 IIALASAYLVLHPYGVEIANIASYLSEMLRNNAAPSNHDDLANILGKYTNLFKPE--------KE 786
            ::.:.|.:|.:||:|..|..|.|||..:    ....:..::.::||:....||.|        ::
Zfish   612 LVGIISTFLHVHPFGASIEYICSYLQRL----DTKISTTEVESLLGRLPCTFKQELTGVGASLEK 672

  Fly   787 KWRFCGF 793
            :|:||||
Zfish   673 RWKFCGF 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10948	NP_729844.1	RRM_ENOX	228..311	CDD:240674	50/82 (61%)
CG10948	NP_729844.1	RRM	<234..>318	CDD:223796	50/83 (60%)
enox2	XP_005173205.1	Forkhead_N	<70..>127	CDD:254796	22/111 (20%)
		RRM	<162..>240	CDD:223796	45/77 (58%)
		RRM_ENOX	165..248	CDD:240674	50/82 (61%)
		DUF4763	416..>540	CDD:292582	46/139 (33%)
		SH3_and_anchor	<490..620	CDD:275056	41/209 (20%)
		FlxA	497..>550	CDD:290980	20/96 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596556
Domainoid	1	1.000	262	1.000	Domainoid score	I1904
eggNOG	1	0.900	-	-		E1_28HXJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1899
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D178870at33208
OrthoFinder	1	1.000	-	-		FOG0003519
OrthoInspector	1	1.000	-	-		otm25167
orthoMCL	1	0.900	-	-		OOG6_106905
Panther	1	1.100	-	-	LDO	PTHR16001
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5196
SonicParanoid	1	1.000	-	-		X3404
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790