Protein Alignment CG10948 and ENOX1

DIOPT Version :10

• Sequence 1: NP_729844.1
• Gene: CG10948 / 39459
• FlyBaseID: FBgn0036317
• Length: 804
• Species: Drosophila melanogaster
• Sequence 2: NP_001334892.1
• Gene: ENOX1 / 55068
• HGNCID: 25474
• Length: 678
• Species: Homo sapiens
• Alignment Length: 807
• Identity: 269/807 - (33%)
• Similarity: 411/807 - (50%)
• Gaps: 183/807 - (22%)

  Fly    29 STAASSTSVVGNPSSPPKQIQNKMAKQQQQPQGSAPMDLENENEHSADVSSSTM--HKEPKLQAT 91
            |..:.|..:.|:|:          ...|..|   ||:|..|....:..|.:.|.  .:.|::.|.
Human     7 SPCSESDDLRGDPA----------LSHQSVP---APLDTHNSMVDAGGVENITQLPQELPQMMAA 58

  Fly    92 S----NSLTLPDSTQLYLNGLVHTPPGYLYFPATQAGGATAPGNPSSAAGGSTPAASANSTANAQ 152
            :    .|:.: |:||  ||..|..|..:          |||..|......| .|.....|.:...
Human    59 AADGLGSIAI-DTTQ--LNMSVTDPTAW----------ATAMNNLGMVPVG-LPGQQLVSDSICV 109

  Fly   153 MLMDPTAMMAAAMQQMQQMHYAAAAAAGMTTETGAGLEATLNADGVTP------AGLKEVIKTKN 211
            ...||:..|...:..:..|            ..|.||        |.|      |.:||:|..|:
Human   110 PGFDPSLNMMTGITPINPM------------IPGLGL--------VPPPPPTEVAVVKEIIHCKS 154

  Fly   212 CILFPPNPNAPPPTIRERPPGCRTVFVGGLPENITEEVIREIFESCGEITTLRMSKKNFCHIRYR 276
            |.|||.|||.|||:.|||||||:||||||||||.|||:|:|:||.||:||.:|.|||||||||:.
Human   155 CTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFA 219

  Fly   277 QEGAIDRAIYLSGYRLRISALNEPPNFGRLHVDYAQARDDQYDYECRQRQHQREQRHRERMSMDR 341
            :|..:|:||||||||:|:.:..:..:.||||||:||||||.|::||:||...||:|||.::..||
Human   220 EEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDR 284

  Fly   342 MRSQSPPPIPHYTDHEATTVAEHLRTNETFVKAIQTITAWLERGDCTKRNANVFYSMIQSTHAHV 406
            :|..|||.|.||::|||..:||.|:.:..|.:||..:.:|:|||:..:|:||.||||:||.::||
Human   285 LRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHV 349

  Fly   407 RRLHADKLQLEEDLKKARDSYRNQMGTMSTQFTQIEKVFNAASHKKVWDHFTKAQRKNIDQWKKL 471
            |||..:|...|:::::|:::::|.:..:.|||.||..||||::.:|.||||:||||||||.|:|.
Human   350 RRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKH 414

  Fly   472 ATELRTVQ------ITDDDEMEISDDERDYDRRGHSAKRIRYDSD-------GLKDENDSLRCQL 523
            :.|||..|      |..::|||:||||    ......|::|.|..       .||:||||||.||
Human   415 SEELRNAQSEQLMGIRREEEMEMSDDE----NCDSPTKKMRVDESALAAQAYALKEENDSLRWQL 475

  Fly   524 EAIRHEMTLERSDYVQ---------REKQIKVLQETIRNMQTQLLQTKLREQKDNKTIEQLERNL 579
            :|.|:|:.|.:.:..|         :::|::.||:|::.||.|||  .::|:.:||..| ||:..
Human   476 DAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLL--TIQEELNNKKSE-LEQAK 537

  Fly   580 KDAGIKQLLLKTKIKETVDKLRDKEANSAGASNASNASNLDYSSGDSCSREGTEIIRPQAEPEII 644
            ::....|.|||. ::|.:                                :||:        |::
Human   538 EEQSHTQALLKV-LQEQL--------------------------------KGTK--------ELV 561

  Fly   645 DIDKVDDDVRIIEHQSGVVEIHEIEDDEKQEPAKDSTKSKANESIMENVSKSNHEETINKSSKEQ 709
            :.:         .|.      ||           ||.:.......:.|..:.|:.|..::..|.:
Human   562 ETN---------GHS------HE-----------DSNEINVLTVALVNQDRENNIEKRSQGLKSE 600

  Fly   710 IPTVAAEEVTFKSLVLSEAKIIALASAYLVLHPYGVEIANIASYLSEMLRNNAAPSNHDDLANIL 774
                            .||.:|.:.|.:|.:||:|..|..:.||:.::....:|    :::..:|
Human   601 ----------------KEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISA----NEIEMLL 645

  Fly   775 GKYTNLFKPE--------KEKWRFCGF 793
            .:...:||.|        :::|:.|.|
Human   646 MRLPRMFKQEFTGVGATLEKRWKLCAF 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10948	NP_729844.1	RRM_ENOX	228..311	CDD:409675	54/82 (66%)
		SMC_prok_B	404..>606	CDD:274008	83/223 (37%)
		Smc	<512..>740	CDD:440809	52/236 (22%)
ENOX1	NP_001334892.1	RRM_ENOX	171..254	CDD:409675	54/82 (66%)
		SMC_prok_B	270..>617	CDD:274008	136/436 (31%)