DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10948 and Enox2

DIOPT Version :9

Sequence 1:	NP_729844.1	Gene:	CG10948 / 39459	FlyBaseID:	FBgn0036317	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_017457884.1	Gene:	Enox2 / 302817	RGDID:	1563643	Length:	650	Species:	Rattus norvegicus

Alignment Length:	751	Identity:	266/751 - (35%)
Similarity:	385/751 - (51%)	Gaps:	178/751 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 GLVHTPPGYLYFPAT-----QAGGATAP---------GNPSSAAGGSTPAASANSTA-----NAQ 152
            ||...|    :.||.     |.|.|:.|         |..||.....|.|.||::|.     :|.
  Rat     8 GLNQLP----FDPANNNEPLQFGSASGPLVPEGLIENGGESSKKRKRTNAPSADNTRTLNVDSAA 68

  Fly   153 MLM---DPTAMMAAAMQQMQQMHYAAAAAAG--MTTETGAGLEATLNADGVTP--AGL------- 203
            |.:   ||||...|    |..:..|....||  :..|....|........:||  .||
  Rat    69 MTLPVSDPTAWATA----MNNLGMAPLGIAGQPILPEFDPALGMMTGIPPITPMMPGLGIVPPPI 129

  Fly   204 -------KEVIKTKNCILFPPNPNAPPPTIRERPPGCRTVFVGGLPENITEEVIREIFESCGEIT 261
                   ||:|..|:|.|||||||.|||..|||||||:||||||||||.||::|.|:||.||||.
  Rat   130 PPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEII 194

  Fly   262 TLRMSKKNFCHIRYRQEGAIDRAIYLSGYRLRISALNEPPNFGRLHVDYAQARDDQYDYECRQRQ 326
            .:|.|||||||||:.:|..:|:|:||||||:|:.:..:..:.||||||:||||||.|::||:||.
  Rat   195 AIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRM 259

  Fly   327 HQREQRHRERMSMDRMRSQSPPPIPHYTDHEATTVAEHLRTNETFVKAIQTITAWLERGDCTKRN 391
            ..||:|||.||..:|||..||||:.||:|||.:.|||.|:.:..|.:|:||:..|:|||:..:|:
  Rat   260 LAREERHRRRMEEERMRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRS 324

  Fly   392 ANVFYSMIQSTHAHVRRLHADKLQLEEDLKKARDSYRNQMGTMSTQFTQIEKVFNAASHKKVWDH 456
            ||.|||||||.::|||||..:|...|:::::|::.::..:..:..||.||..|:::||.:|.|||
  Rat   325 ANHFYSMIQSANSHVRRLVNEKAAHEKEMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDH 389

  Fly   457 FTKAQRKNIDQWKKLATELRTVQ------ITDDDEMEISDD--ERDYDRRGHSAKRIRYDSDGLK 513
            |||||||||..|.|.|.|:|.:.      |..::|||:|||  |...:.:......:...::.||
  Rat   390 FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEETTETKETEESALVSQAEALK 454

  Fly   514 DENDSLRCQLEAIRHEMTL--------ERSDYVQREKQIKVLQETIRNMQTQLLQTKLREQKDNK 570
            :||||||.||:|.|:|:.|        .|.|...:|:|:|:||:.::.||..||  |::|:...|
  Rat   455 EENDSLRWQLDAYRNEVELLKQEQGKAHREDDPNKEQQLKLLQQALQGMQQHLL--KVQEEYKKK 517

  Fly   571 TIEQLERNLKDAGIKQLLLKTKIKETVDKLRDKEANSAGASNASNASNLDYSSGDSCSREGTEII 635
            ..| |:| :||.       |.::::.::.|.:|:.|.        .|.|..||.:|
  Rat   518 EAE-LDR-IKDD-------KLQVEKLLENLHEKQENC--------TSRLCASSQES--------- 556

  Fly   636 RPQAEPEIIDIDKVDDDVRIIEHQSGVVEIHEIEDDEKQEPAKDSTKSKANESIMENVSKSNHEE 700
                                         .|.:|                 ::|:.|..||..
  Rat   557 -----------------------------DHPLE-----------------KAIIGNPVKSER-- 573

  Fly   701 TINKSSKEQIPTVAAEEVTFKSLVLSEAKIIALASAYLVLHPYGVEIANIASYLSEMLRNNAAPS 765
                                      ||.::.:.|.:|.:||:|..|..|.|||:. |.|....|
  Rat   574 --------------------------EALLVGIISTFLHVHPFGASIEYICSYLNR-LDNKICTS 611

  Fly   766 NHDDLANILGKYTNLFKPE--------KEKWRFCGF 793
               |:.:::.:..:.|:.|        :::|:||||
  Rat   612 ---DVESLMSRLQHTFRQEMTGVGASLEKRWKFCGF 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10948	NP_729844.1	RRM_ENOX	228..311	CDD:240674	52/82 (63%)
CG10948	NP_729844.1	RRM	<234..>318	CDD:223796	52/83 (63%)
Enox2	XP_017457884.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354277
Domainoid	1	1.000	255	1.000	Domainoid score	I1970
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1895
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D178870at33208
OrthoFinder	1	1.000	-	-		FOG0003519
OrthoInspector	1	1.000	-	-		otm45877
orthoMCL	1	0.900	-	-		OOG6_106905
Panther	1	1.100	-	-	LDO	PTHR16001
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3404
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900