DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10948 and ENOX2

DIOPT Version :9

Sequence 1:	NP_729844.1	Gene:	CG10948 / 39459	FlyBaseID:	FBgn0036317	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001369447.1	Gene:	ENOX2 / 10495	HGNCID:	2259	Length:	673	Species:	Homo sapiens

Alignment Length:	768	Identity:	274/768 - (35%)
Similarity:	398/768 - (51%)	Gaps:	178/768 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 TSNSLTLPDSTQ---LYLNGLVHTPPGYLYFPAT-----QAGGATAP---------GNPSS--AA 136
            |:::.|..|.|.   |..:||...|    :.||.     |.|.|:.|         |..||  ..
Human    13 TASAATNKDETNCNFLISSGLNQLP----FDPANNNEPLQFGSASGPLVTEGLIENGGESSKKRK 73

  Fly   137 GGSTPAA------SANSTANAQMLMDPTAMMAAAMQQMQQMHYAAAA---------AAGMTTETG 186
            ..:||:|      :.:|||....:.|||| .|.||..:.......|.         |.||.|..
Human    74 RTNTPSADNSRTLNVDSTAMTLPMSDPTA-WATAMNNLGMAPLGIAGQPILPDFDPALGMMTGI- 136

  Fly   187 AGLEATLNADGVTPAGL-------KEVIKTKNCILFPPNPNAPPPTIRERPPGCRTVFVGGLPEN 244
            ..:...:...|:.|..:       ||:|..|:|.|||||||.|||..|||||||:||||||||||
Human   137 PPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPEN 201

  Fly   245 ITEEVIREIFESCGEITTLRMSKKNFCHIRYRQEGAIDRAIYLSGYRLRISALNEPPNFGRLHVD 309
            .||::|.|:||.||||..:|.|||||||||:.:|..:|:|:||||||:|:.:..:..:.||||||
Human   202 GTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVD 266

  Fly   310 YAQARDDQYDYECRQRQHQREQRHRERMSMDRMRSQSPPPIPHYTDHEATTVAEHLRTNETFVKA 374
            :||||||.|::||:||...||:|||.||..:|:|..||||:.||:|||.:.|||.|:.:..|.:|
Human   267 FAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEA 331

  Fly   375 IQTITAWLERGDCTKRNANVFYSMIQSTHAHVRRLHADKLQLEEDLKKARDSYRNQMGTMSTQFT 439
            :||:..|:|||:..:|:||.|||||||.::|||||..:|...|:|:::|::.::..:..:..||.
Human   332 VQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFE 396

  Fly   440 QIEKVFNAASHKKVWDHFTKAQRKNIDQWKKLATELRTVQ------ITDDDEMEISDDERD--YD 496
            ||..|:::||.:|.||||||||||||..|.|.|.|:|.:.      |..::|||:||||.:  .:
Human   397 QIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTE 461

  Fly   497 RRGHSAKRIRYDSDGLKDENDSLRCQLEAIRHEMTL--------ERSDYVQREKQIKVLQETIRN 553
            .:......:...::.||:||||||.||:|.|:|:.|        .|.|...:|:|:|:||:.::.
Human   462 TKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQG 526

  Fly   554 MQTQLLQTKLREQKDNKTIEQLERNLKDAGIKQLLLKTKIKETVDKLRDKEANSAGASNASNASN 618
            ||..||  |::|:...|..| ||: |||.       |.::::.::.|::||         |.||.
Human   527 MQQHLL--KVQEEYKKKEAE-LEK-LKDD-------KLQVEKMLENLKEKE---------SCASR 571

  Fly   619 LDYSSGDSCSREGTEIIRPQAEPEIIDIDKVDDDVRIIEHQSGVVEIHEIEDDEKQEPAKDSTKS 683
            |..|:.||                                               :.|.
Human   572 LCASNQDS-----------------------------------------------EYPL------ 583

  Fly   684 KANESIMENVSKSNHEETINKSSKEQIPTVAAEEVTFKSLVLSEAKIIALASAYLVLHPYGVEIA 748
                           |:|:|.|      .:.:|.         ||.::.:.|.:|.:||:|..|.
Human   584 ---------------EKTMNSS------PIKSER---------EALLVGIISTFLHVHPFGASIE 618

  Fly   749 NIASYLSEMLRNNAAPSNHDDLANILGKYTNLFKPE--------KEKWRFCGF 793
            .|.||| ..|.|....|   |:..::|:..:.||.|        :::|:||||
Human   619 YICSYL-HRLDNKICTS---DVECLMGRLQHTFKQEMTGVGASLEKRWKFCGF 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10948	NP_729844.1	RRM_ENOX	228..311	CDD:240674	52/82 (63%)
CG10948	NP_729844.1	RRM	<234..>318	CDD:223796	52/83 (63%)
ENOX2	NP_001369447.1	RRM_ENOX	185..268	CDD:409675	52/82 (63%)
ENOX2	NP_001369447.1	Smc	<356..>589	CDD:224117	93/320 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160206
Domainoid	1	1.000	257	1.000	Domainoid score	I2026
eggNOG	1	0.900	-	-		E1_28HXJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1955
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D178870at33208
OrthoFinder	1	1.000	-	-		FOG0003519
OrthoInspector	1	1.000	-	-		otm41745
orthoMCL	1	0.900	-	-		OOG6_106905
Panther	1	1.100	-	-	LDO	PTHR16001
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3404
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760