DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10948 and enox1

DIOPT Version :9

Sequence 1:	NP_729844.1	Gene:	CG10948 / 39459	FlyBaseID:	FBgn0036317	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_031752986.1	Gene:	enox1 / 100486899	XenbaseID:	XB-GENE-955953	Length:	722	Species:	Xenopus tropicalis

Alignment Length:	820	Identity:	263/820 - (32%)
Similarity:	412/820 - (50%)	Gaps:	193/820 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 STSVVGNPSSPPKQIQNKMAKQQQ-QPQGSAPMDLENENEHSAD-VSSSTMHKEPKLQATSN--- 93
            :.||:|.|         ||.:..: .|   |..|:|...:...| :..||::|:..:....|
Frog    30 AVSVIGYP---------KMVRVTRFSP---ADPDVEKAIKELNDLLVDSTINKKAFMSQNDNQAI 82

  Fly    94 -SLTLPDSTQLYLNGLVHTPPGYLYFPATQAGGATAPGNPSSAAGGSTPAASANSTANAQML--- 154
             ::::.:.|:......|.|     ...|..|.|:.|..........:.|.|.|.:..|..|:
Frog    83 RNISIVERTERQQTESVET-----MATAADALGSIAIDATHLTMSVTDPTAWATAMNNLGMVPVG 142

  Fly   155 ---------------MDPTAMMAAAMQQMQQMHYAAAAAAGMTTETGAGLEATLNADGVTPAG-- 202
                           .||:..|...:.|:..|      .|||               |:.|..
Frog   143 LAGQQLVSDSICVPGFDPSLSMMTGITQINPM------MAGM---------------GLLPPPPT 186

  Fly   203 ----LKEVIKTKNCILFPPNPNAPPPTIRERPPGCRTVFVGGLPENITEEVIREIFESCGEITTL 263
                :||:|..|:|.|||||||.|||:.|||||||:||||||||||.|||:|:|:||.||:||.:
Frog   187 QLPIVKEIIHCKSCTLFPPNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQELFEQCGDITAI 251

  Fly   264 RMSKKNFCHIRYRQEGAIDRAIYLSGYRLRISALNEPPNFGRLHVDYAQARDDQYDYECRQRQHQ 328
            |.|||||||||:.:|..:|:||||||||:|:.:..:..:.||||||:||||||.|::||:||...
Frog   252 RKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMLA 316

  Fly   329 REQRHRERMSMDRMRSQSPPPIPHYTDHEATTVAEHLRTNETFVKAIQTITAWLERGDCTKRNAN 393
            ||:|||.::.:|::|..|||.|.||::||||.:||.|:.:..|.:||..:..|:|||:..:|:||
Frog   317 REERHRRKLEVDKLRPPSPPAIMHYSEHEATMLAEKLKDDNKFCEAITVLLTWIERGEVNRRSAN 381

  Fly   394 VFYSMIQSTHAHVRRLHADKLQLEEDLKKARDSYRNQMGTMSTQFTQIEKVFNAASHKKVWDHFT 458
            .|||||||.::|||||..:|...||.:::|:::::..:..:.|||.||..||||::.:|.||||:
Frog   382 QFYSMIQSANSHVRRLMNEKAADEEIMEQAKETFKTALFGILTQFEQIVAVFNASTRQKAWDHFS 446

  Fly   459 KAQRKNIDQWKKLATELRTVQ------ITDDDEMEISDDERDYDRRGHSAKRIRYDSD------- 510
            ||||||||.|:|...:||..|      |..::|||:|||    |......|:.|.|..
Frog   447 KAQRKNIDIWRKHCEDLRNAQSEQLMGIRREEEMEMSDD----DSSDIPNKKARLDDSALAAQAY 507

  Fly   511 GLKDENDSLRCQLEAIRHEMTL---------ERSDYVQREKQIKVLQETIRNMQTQLLQTKLREQ 566
            .||:||||||.||:|.|:|:.|         ...:.:.:::|::.||:|::.||.||  ..::|:
Frog   508 ALKEENDSLRWQLDAYRNEVDLLKQEKGHHGRTEESLTKDQQLQFLQQTMQTMQQQL--AAMQEE 570

  Fly   567 KDNKTIEQLERNLKDAGIKQLLLKTKIKETVDKLRDKEANSAGASNASNASNLDYSSGDSCSREG 631
            .:||                       |..::|.::::.::...
Frog   571 LNNK-----------------------KSELEKAKEEQTHAHAL--------------------- 591

  Fly   632 TEIIRPQAEPEIIDIDKVDDDVRIIEHQSGVVEIHEIEDDEKQEPAKDSTKSKANESIMENVSKS 696
                                 |.:::.|  :....|:.|...||.....|.:       .:|:..
Frog   592 ---------------------VSVLKEQ--LKSAKEVTDVTNQEYLSKETST-------VSVAVY 626

  Fly   697 NHEETINKSSKEQIPTVAAEEVTFKSLVLSEAKIIALASAYLVLHPYGVEIANIASYLSEMLRNN 761
            ||::  .|.:::|..::.:|:         ||.:|.:.|.:|.:||:|.....:.|||.::....
Frog   627 NHDK--EKDAEKQRQSLKSEK---------EALLIGIISTFLNVHPFGANTEYLWSYLQQLDSTI 680

  Fly   762 AAPSNHDDLANILGKYTNLFKPE--------KEKWRFCGF 793
            :|    :::..:|.|...:||.|        :::|:||.|
Frog   681 SA----NEIETLLTKLPRMFKQEFTGVGATLEKRWKFCAF 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10948	NP_729844.1	RRM_ENOX	228..311	CDD:240674	54/82 (66%)
CG10948	NP_729844.1	RRM	<234..>318	CDD:223796	54/83 (65%)
enox1	XP_031752986.1	RRM_ENOX	216..299	CDD:409675	54/82 (66%)
enox1	XP_031752986.1	SMC_prok_B	<393..>648	CDD:274008	88/345 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	243	1.000	Domainoid score	I2171
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56793
Inparanoid	1	1.050	388	1.000	Inparanoid score	I1969
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D178870at33208
OrthoFinder	1	1.000	-	-		FOG0003519
OrthoInspector	1	1.000	-	-		oto104525
Panther	1	1.100	-	-	O	PTHR16001
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5196
SonicParanoid	1	1.000	-	-		X3404
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190