DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10960 and HXT1

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_011962.1	Gene:	HXT1 / 856494	SGDID:	S000001136	Length:	570	Species:	Saccharomyces cerevisiae

Alignment Length:	547	Identity:	142/547 - (25%)
Similarity:	239/547 - (43%)	Gaps:	64/547 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KKSGSNNEESSHLLESAENGAKYGSRQPVKIVKASDNGRTSSTPHDQENLLGNMVHTSTS-NNSQ 79
            :||.|:|   |:.|||..:.|           ..:..|:..|. ||  ||..:.|..:.: .|:.
Yeast    11 QKSNSSN---SYELESGRSKA-----------MNTPEGKNESF-HD--NLSESQVQPAVAPPNTG 58

  Fly    80 KWPQYVAALAAAGGAFAAGTVLGWTS------PAETEIVDR-------GEGYDFPVDKDQFSWVG 131
            |......::.....|| .|.:.||.:      .|:|:.:.|       |..|   :.|.:...:.
Yeast    59 KGVYVTVSICCVMVAF-GGFIFGWDTGTISGFVAQTDFLRRFGMKHHDGSHY---LSKVRTGLIV 119

  Fly   132 SAMTLGAACVCIPIGFLINMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLY-ASRFILGIAGGAF 195
            |...:|.|...|.:..|.:|.||:..::.:|:.:.:|..:.|.::|....| ..|.|.|:..|..
Yeast   120 SIFNIGCAIGGIVLAKLGDMYGRRIGLIVVVVIYTIGIIIQIASINKWYQYFIGRIISGLGVGGI 184

  Fly   196 CVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVKIFWLSI-------ICGILPLIF 253
            .|.:||...|:|..|:||||.|.:|:|||:||...|....|.|.:..|:       :|....|..
Yeast   185 TVLSPMLISEVAPSEMRGTLVSCYQVMITLGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFM 249

  Fly   254 GAIFFFMPESPTYLVSKDRSENAIKSIQWLRGKEYDY---EPELAELRETDRETKANKVNVWAAL 315
            .....|:||||.|||...|.:.|..|:..:.....|:   :.||..:..:..|.:|.....|..|
Yeast   250 IGGMMFVPESPRYLVEAGRIDEARASLAKVNKCPPDHPYIQYELETIEASVEEMRAAGTASWGEL 314

  Fly   316 --NRPVTRKALAISMGLMFFQQVCGINAVIFYASRIFLEANTGIEAEWAT-ILIGIMQVVATFVS 377
              .:|...:...:.:.:...||:.|.|...:|.:.:|  ...|:...:.| |:.|::...:|..|
Yeast   315 FTGKPAMFQRTMMGIMIQSLQQLTGDNYFFYYGTIVF--QAVGLSDSFETSIVFGVVNFFSTCCS 377

  Fly   378 TLVVDKLGRRILLLASGISMA---ISTTAIGV-YFFLQKQDAAQVVSLGWLPVASLCLFIIMFSI 438
            ...||:.|||..|:...:.|.   :...::|| ..:...||.......|...:...|.:|..|:.
Yeast   378 LYTVDRFGRRNCLMWGAVGMVCCYVVYASVGVTRLWPNGQDQPSSKGAGNCMIVFACFYIFCFAT 442

  Fly   439 GYGPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVVT--KTFVN--LNDGLGIGGTFWLFAGLT 499
            .:.|:.::::.|.|...:|....|:|..:||:..|:::  ..|:.  :|...|     ::|.|..
Yeast   443 TWAPIAYVVISECFPLRVKSKCMSIASAANWIWGFLISFFTPFITGAINFYYG-----YVFMGCM 502

  Fly   500 VVGVIFVYFAVPETKGKSLNEIQQELA 526
            |....:|:|.||||||.||.|:....|
Yeast   503 VFAYFYVFFFVPETKGLSLEEVNDMYA 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	96/374 (26%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	104/411 (25%)
HXT1	NP_011962.1	Sugar_tr	68..528	CDD:395036	123/470 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342283
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	6	5.640