DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10960 and HXT14

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_014081.1	Gene:	HXT14 / 855398	SGDID:	S000005262	Length:	540	Species:	Saccharomyces cerevisiae

Alignment Length:	519	Identity:	131/519 - (25%)
Similarity:	221/519 - (42%)	Gaps:	81/519 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 QENLLGNMVHTSTSNNSQKWPQYVAALAAAGG---AFAAGTVLGWTSPAE-------TEIVDRGE 116
            :||:.|.....| .|.|...|..:..:.:.||   .:..||:.|.|:...       |.|:...|
Yeast    41 EENIEGQAAKIS-HNASLHIPVLLCLVISLGGFIFGWDIGTIGGMTNMVSFQEKFGTTNIIHDDE 104

  Fly   117 GYDFPVDK--D-QFSWVGSAMTLGAACVCIPIGFLINMIGRKWTMLFLVLPFILGWTMLI----- 173
            .......|  | |...:.|...:......:.:..:.:.||||..:.|.::.:.:|.|:.|
Yeast   105 TIFVSTKKLTDLQIGLIISIFNISCGVGALTLSKIGDWIGRKGGIWFALVVYCIGITIQILSYGR 169

  Fly   174 WAVNVSMLYASRFILGIAGGAFCVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVG---- 234
            |    ..|...|.:.||..|...|..||:..|.:..:|||::.|.:||::|.|||....:.
Yeast   170 W----YFLTLGRAVTGIGVGVTTVLVPMFLSENSPLKIRGSMVSTYQLIVTFGILMGNILNFICE 230

  Fly   235 -----AGVKIFW-LSIICG-ILPLIFGAIFFFMPESPTYLVS-KDRSENAIKSIQWLRG------ 285
                 ....|.| |.:..| |..:|.|....::||||.||.. |:...:|..|...:.|
Yeast   231 RCYKDPTQNIAWQLPLFLGYIWAIIIGMSLVYVPESPQYLAKIKNDVPSAKYSFARMNGIPATDS 295

  Fly   286 ---------KEYDYEPELAELRETDRETKAN---KVNVWA-ALNRPVTRKALAISMGLMFFQQVC 337
                     .|.:|..|     ||:.|:|..   |.|.:. .:.:|.....|.|.|.:|.|||:.
Yeast   296 MVIEFIDDLLENNYNNE-----ETNNESKKQSLVKRNTFEFIMGKPKLWLRLIIGMMIMAFQQLS 355

  Fly   338 GINAVIFYASRIFLEANTGIEAEWAT-ILIGIMQVVATFVSTLVVDKLGRRILLLASGISM---A 398
            |||...:|.:.:|  ...||:..:.| |::..:..::|.:....|:|.|.:..||....::   .
Yeast   356 GINYFFYYGTSVF--KGVGIKDPYITSIILSSVNFLSTILGIYYVEKWGHKTCLLYGSTNLLFYM 418

  Fly   399 ISTTAIGVYFFLQKQDAAQVVSLGWLPVASLCLFIIMFSIGYGPVPWLMMGELFATDIKGFAGSL 463
            ::...:|.  |.::.|.:.:|.     :...|.||..|:|..|||.::::.|||....:..:.::
Yeast   419 MTYATVGT--FGRETDFSNIVL-----IIVTCCFIFWFAITLGPVTFVLVSELFPLRTRAISMAI 476

  Fly   464 AGTSNWLLAFVV---TKTFVNLND-GLGIGGTFWLFAGLTVVGVIFVYFAVPETKGKSLNEIQQ 523
            ....||:..|::   |...|:..| .||     ::||...:..:||.:..||||:.|:..||.:
Yeast   477 CTFINWMFNFLISLLTPMIVSKIDFKLG-----YIFAACLLALIIFSWILVPETRKKNEQEINK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	98/399 (25%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	108/436 (25%)
HXT14	NP_014081.1	MFS_HXT	62..537	CDD:340914	124/497 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	5	4.710