DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10960 and ATR2

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_014006.1	Gene:	ATR2 / 855322	SGDID:	S000004892	Length:	540	Species:	Saccharomyces cerevisiae

Alignment Length:	574	Identity:	108/574 - (18%)
Similarity:	196/574 - (34%)	Gaps:	197/574 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VKASDNGRTSSTPHDQENLLGNMVHTSTSNNSQKW--PQY---------------VAALAAAGGA 94
            |||.|....|:...:...::.:...|..:|:| .|  |.|               :|.|....|.
Yeast    24 VKAKDKVVVSTEDEEVTTIVSSTKSTQVTNDS-PWQDPTYFSSFGKELMFIATCMLAQLLNQAGQ 87

  Fly    95 FAAGTVLGWTSPAETEIVDRGEGYDFPVDKDQFSWVGSAMTLGAACVCIPIGFLINMIGRKWTML 159
            ..|..::...|.:            |..:.:..:|:.::..|.|....:..|.|.::.|.|   .
Yeast    88 THALCIMNVLSKS------------FNSEANNQAWLMASFPLAAGSFILISGRLGDIYGLK---K 137

  Fly   160 FLVLPFILGWTMLIWAVNVSMLYASRFILGIA----GGAFCVTAPMYTGEIAQKEIRGTLGSFFQ 220
            .|::.:::   :::|::          |.|::    ..||.:|:..:.|          :|..|.
Yeast   138 MLIVGYVI---VIVWSI----------ISGLSKYSNSDAFFITSRAFQG----------VGIAFI 179

  Fly   221 LMITIGIL-FVYAVGAGVKIFWLSIICGILPL--IFGAIF--FFMPESPTYLVSKDRSENAIKSI 280
            |...:|:: .||.||:..|...:|.|....|.  :||.:|  ..:.|.|.
Yeast   180 LPNIMGLVGHVYKVGSFRKNIVISFIGACAPTGGMFGGLFGGLIVTEDPN--------------- 229

  Fly   281 QWLRGKEYDYEPELAELRETDRETKANKVNVWAAL--NRPV---------TRKALAISMGLMFFQ 334
            ||   ....|...:|        |..:.:..|.::  |.|.         |..|||| :||:.|.
Yeast   230 QW---PWVFYAFGIA--------TFLSLLMAWYSIPNNVPTNIHGLSMDWTGSALAI-IGLILFN 282

  Fly   335 QVCGINAVIFYASRIFLEANTGIEAEWATILIGIMQVVATFVSTLVVDKL---------GRRILL 390
            .|.....::.:.....:          ..::|.::.:||.||......::         .|.:::
Yeast   283 FVWNQAPIVGWDKPYII----------VLLIISVIFLVAFFVYESKYAEVPLLPRAMTKNRHMIM 337

  Fly   391 LASGISMAISTTAIGVYFFLQKQDAAQVVSLGW--------LPVASLCLFIIMFSI-GYGPVPWL 446
            :...:.:...:..|..::::..|...:..|..|        :...|:..|.:.||| ..||. .|
Yeast   338 ILLAVFLGWGSFGIWTFYYVSFQLNLRHYSPVWTGGTYFVFVIFGSMAAFFVAFSIKRLGPA-LL 401

  Fly   447 MMGELFATDIKGFAGSL------AGTSNW--------LLAFVVTKTF----VNLNDG-------- 485
            :...|.|.|    |||:      ...|.|        :|.|.:..:|    :.|:||
Yeast   402 LCFSLMAFD----AGSIMFSVLPVEQSYWKLNFAMQAILCFGMDLSFPASSIILSDGLPMQYQGM 462

  Fly   486 ----------------LGIGGT-------------------FWLFAGLTVVGVI 504
                            ||:|||                   .:|..||..:||:
Yeast   463 AGSLVNTVINYSASLCLGMGGTVEHQINKSGNDLLKGYRAAVYLGVGLASLGVV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	77/408 (19%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	92/486 (19%)
ATR2	NP_014006.1	MFS_Amf1_MDR_like	74..519	CDD:341029	97/523 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900