DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10960 and ATR1

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_013591.1	Gene:	ATR1 / 854924	SGDID:	S000004584	Length:	542	Species:	Saccharomyces cerevisiae

Alignment Length:	580	Identity:	106/580 - (18%)
Similarity:	197/580 - (33%)	Gaps:	147/580 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LLESAENGAKYGSRQPVKIVKAS-DNG------RTSSTPHDQENLLGNMVHTSTSNNSQKWPQY- 84
            |:...|:..:|.:...:.:.|:| ||.      .|:.|..:.|.:..|....:.:.....|.:|
Yeast     6 LVVLTESKGEYENETELPVKKSSRDNNIGESLTATAFTQSEDEMVDSNQKWQNPNYFKYAWQEYL 70

  Fly    85 ------VAALAAAGGAFAAGTVLGWTSPAETEIVDRGEGYDFPVDKDQFSWVGSAMTLGAACVCI 143
                  ::.|....|.....:::...|.:            |..:.:..||:.::..|.:....:
Yeast    71 FIFTCMISQLLNQAGTTQTLSIMNILSDS------------FGSEGNSKSWLMASFPLVSGSFIL 123

  Fly   144 PIGFLINMIGRKWTMLFLVLPFILGWTMLIWAVNVS----MLYASRFILGIAGGAFCVTAPMYTG 204
            ..|.|.::.|.| .||.:....::.|:::......|    ....||...|: |.||.:  |...|
Yeast   124 ISGRLGDIYGLK-KMLLVGYVLVIIWSLICGITKYSGSDTFFIISRAFQGL-GIAFVL--PNVLG 184

  Fly   205 EIAQKEIRGT---------LGSFFQLMITIGILF------------------------------V 230
            .|....:.||         :|:...:..|:|.||                              :
Yeast   185 IIGNIYVGGTFRKNIVISFVGAMAPIGATLGCLFAGLIGTEDPKQWPWAFYAYSIAAFINFVLSI 249

  Fly   231 YAVGAGV-------KIFWLSIICGILPLIFGAIFFFMPESP------TYLVSKDRSENAIKSIQW 282
            ||:.:.:       .:.|:..:.|::.||.  :.|...::|      .|::     ...|.|:.:
Yeast   250 YAIPSTIPTNIHHFSMDWIGSVLGVIGLIL--LNFVWNQAPISGWNQAYII-----VILIISVIF 307

  Fly   283 LRGKEYDYEPELAELRETDRETKANKVNVWAALNRPV--TRKALAISMGLMFFQQVCGINAVIFY 345
            | .....||...|:.               ..|.|.|  .|..:.|.:.|.|.....||....::
Yeast   308 L-VVFIIYEIRFAKT---------------PLLPRAVIKDRHMIQIMLALFFGWGSFGIFTFYYF 356

  Fly   346 ASRIFLEANTGIEAEWATILIGIMQVVATFVSTLVVDKLGRRILLLAS------GISMAISTTAI 404
            ..::.:...|.:.|.....:..|..::|..:....:..:...:.|..|      |..||..|...
Yeast   357 QFQLNIRQYTALWAGGTYFMFLIWGIIAALLVGFTIKNVSPSVFLFFSMVAFNVGSIMASVTPVH 421

  Fly   405 GVYFFLQKQDAAQVVSLGWLPVASLCLFIIMFSIGYG-PVPWLMMGELFATDIKGFAGSLAGT-S 467
            ..||..|         ||       .:.|:.|.:... |...::..:....:.:|.||||..| .
Yeast   422 ETYFRTQ---------LG-------TMIILSFGMDLSFPASSIIFSDNLPMEYQGMAGSLVNTVV 470

  Fly   468 NWLLAF-----VVTKTFVNLNDG----LGIGGTFWLFAGLTVVGVIF--VYFAVPETKGK 516
            |:.::.     ...:|.|| :||    .|..|..:|..||..:..:.  :|......||:
Yeast   471 NYSMSLCLGMGATVETQVN-SDGKHLLKGYRGAQYLGIGLASLACMISGLYMVESFIKGR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	77/427 (18%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	87/466 (19%)
ATR1	NP_013591.1	MFS_Amf1_MDR_like	73..517	CDD:341029	90/499 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900