DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10960 and HXT11

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_014486.1	Gene:	HXT11 / 854009	SGDID:	S000005516	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	601	Identity:	142/601 - (23%)
Similarity:	240/601 - (39%)	Gaps:	147/601 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SGSNNEESSHLLESAENGAKYGSRQPVKIVKASDNGRTSSTPH-DQENLLGNMVHTSTSNNSQK- 80
            ||.||..::.|..:..|.........||            |.| |.:|.|....:....:..||
Yeast     2 SGVNNTSANELSTTMSNSNSAVGAPSVK------------TEHGDSKNSLNLDANEPPIDLPQKP 54

  Fly    81 WPQY----VAALAAAGGAFAAGTVLGWTSPAETEIV-------------DRGEGYDFPVDKDQFS 128
            ...|    :..|..|.|.|    :.||.:...:..|             |:|..|   :.|.:..
Yeast    55 LSAYTTVAILCLMIAFGGF----IFGWDTGTISGFVNLSDFIRRFGQKNDKGTYY---LSKVRMG 112

  Fly   129 WVGSAMTLGAACVCIPIGFLINMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLY-ASRFILGIAG 192
            .:.|...:|.|...|.:..:.::.||:..::.:...:::|..:.|.::|....| ..|.|.|:..
Yeast   113 LIVSIFNIGCAIGGIVLSKVGDIYGRRIGLITVTAIYVVGILIQITSINKWYQYFIGRIISGLGV 177

  Fly   193 GAFCVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYA---------------VGAGVKIFWL 242
            |...|.:||...|:|.|.|||||...:|||.|:||...|.               ||.|:...|.
Yeast   178 GGIAVLSPMLISEVAPKHIRGTLVQLYQLMGTMGIFLGYCTNYGTKNYHNATQWRVGLGLCFAWA 242

  Fly   243 S-IICGILPLIFGAIFFFMPESPTYLVSKDRSENAIKSIQWLRGKEYDYEPELAELRETDRETKA 306
            : ::.|::         |:||||.||:...:.|.|.:|:                       :|:
Yeast   243 TFMVSGMM---------FVPESPRYLIEVGKDEEAKRSL-----------------------SKS 275

  Fly   307 NKVNV--------------------------WAALNRPVTRKALAISMGLMF--FQQVCGINAVI 343
            |||:|                          |:.|....|:....:.||:|.  .||:.|.|...
Yeast   276 NKVSVDDPALLVEYDTIKAGIELEKLAGNASWSELLSTKTKVFQRVLMGVMIQSLQQLTGDNYFF 340

  Fly   344 FYASRIFLEANTGIEAEWAT-ILIGIMQVVATFVSTLVVDKLGRRILLLASGISMAIS---TTAI 404
            :|.:.||  .:.|::..:.| |:||::...::|::...:::.|||..||....||...   ..::
Yeast   341 YYGTTIF--KSVGLKDSFQTSIIIGVVNFFSSFIAVYTIERFGRRTCLLWGAASMLCCFAVFASV 403

  Fly   405 GV-YFFLQKQDAAQVVSLGWLPVASLCL------FIIMFSIGYGPVPWLMMGELFATDIKGFAGS 462
            || ..:.|......:.|.|    |..|:      ||..|:..:....::::.|.|...:|....:
Yeast   404 GVTKLWPQGSSHQDITSQG----AGNCMIVFTMFFIFSFATTWAGGCYVIVSETFPLRVKSRGMA 464

  Fly   463 LAGTSNWLLAFVVT--KTFVN--LNDGLGIGGTFWLFAGLTVVGVIFVYFAVPETKGKSLNEIQQ 523
            :|..:||:..|:::  ..|:.  :|...|     ::|.|..|....:|:|.||||||.:|.|:
Yeast   465 IATAANWMWGFLISFFTPFITGAINFYYG-----YVFLGCLVFAYFYVFFFVPETKGLTLEEV-- 522

  Fly   524 ELAGNRSTPQAIPAEK 539
                |....:.:||.|
Yeast   523 ----NTMWLEGVPAWK 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	96/412 (23%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	104/449 (23%)
HXT11	NP_014486.1	Sugar_tr	64..526	CDD:395036	123/517 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342297
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9181
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	7	6.640