DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10960 and HXT8

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_012321.1	Gene:	HXT8 / 853216	SGDID:	S000003750	Length:	569	Species:	Saccharomyces cerevisiae

Alignment Length:	549	Identity:	133/549 - (24%)
Similarity:	232/549 - (42%)	Gaps:	72/549 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EEANKKSGSNNEESSHL----LESAENGAKYGSRQPVKIVKASDNGRTSSTPHDQENLLGNMVHT 72
            |||......:.|.||||    :|..::.::|...:..::|.........:|..
Yeast    15 EEAEDDGCPSIENSSHLSVPTVEENKDFSEYNGEEAEEVVVPEKPASAYATVS------------ 67

  Fly    73 STSNNSQKWPQYVAALAAAGGAFAA----GTVLGWTSPAETEIVDRGEGYD-----FPVDKDQFS 128
                        :..|..|.|.|.:    ||:.|:.:  :|:.:.|...|.     :.:...:..
Yeast    68 ------------IMCLCMAFGGFMSGWDTGTISGFVN--QTDFLRRFGNYSHSKNTYYLSNVRTG 118

  Fly   129 WVGSAMTLGAACVCIPIGFLINMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLY-ASRFILGIAG 192
            .:.|...:|:|..|:.:..|.::.||...::.:::.:::|..:.|.:::....| ..|.|.||..
Yeast   119 LIVSIFNVGSAIGCLFLSKLGDIYGRCMGLIIVIVVYMVGIVIQIASIDKWYQYFIGRIIAGIGA 183

  Fly   193 GAFCVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVKIFWLSI-------ICGILP 250
            |:..|.|||...|.|.|.|||||.:.:|||:|..|...|....|.|.:..|:       :|....
Yeast   184 GSISVLAPMLISETAPKHIRGTLLACWQLMVTFAIFLGYCTNYGTKTYSNSVQWRVPLGLCFAWA 248

  Fly   251 LIFGAIFFFMPESPTYLVSKDRSENAIKSIQWLRGKEYDYEPELAELRETDRETKANKVNVWAAL 315
            :|......|:||||.:||...:.|.|..|.........|....:||:.......:|.:....|:.
Yeast   249 IIMIGGMTFVPESPRFLVQVGKIEQAKASFAKSNKLSVDDPAVVAEIDLLVAGVEAEEAMGTASW 313

  Fly   316 NRPVTRKA-----LAISMGLMFFQQVCGINAVIFYASRIFLEANTGIEAEWAT-ILIGIMQVVAT 374
            ....:||.     |.:::.:...||:.|.|...:|.:.||  .:.|:...:.| |::||:...:.
Yeast   314 KELFSRKTKVFQRLTMTVMINSLQQLTGDNYFFYYGTTIF--KSVGMNDSFETSIVLGIVNFASC 376

  Fly   375 FVSTLVVDKLGRRILLLASGISMA---ISTTAIGV-YFFLQKQDAAQVVSLGWLPVASLCLFIIM 435
            |.|...|||||||..||....:|.   :...::|| ..:...:........|...:...|.:|..
Yeast   377 FFSLYSVDKLGRRRCLLLGAATMTACMVIYASVGVTRLYPNGKSEPSSKGAGNCTIVFTCFYIFC 441

  Fly   436 FSIGYGPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVV------TKTFVNLNDGLGIGGTFWL 494
            ||..:|||.::::.|.|...::....|:|..:|.|..|::      ..:.:|...|       ::
Yeast   442 FSCTWGPVCYVIISETFPLRVRSKCMSVATAANLLWGFLIGFFTPFITSAINFYYG-------YV 499

  Fly   495 FAGLTVVGVIFVYFAVPETKGKSLNEIQQ 523
            |.|.......:|:|.||||||.:|.|:.:
Yeast   500 FMGCLAFSYFYVFFFVPETKGLTLEEVDE 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	97/379 (26%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	103/418 (25%)
HXT8	NP_012321.1	Sugar_tr	69..530	CDD:395036	121/471 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342295
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	6	5.640