DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10960 and MAL31

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_009857.1	Gene:	MAL31 / 852601	SGDID:	S000000502	Length:	614	Species:	Saccharomyces cerevisiae

Alignment Length:	610	Identity:	139/610 - (22%)
Similarity:	246/610 - (40%)	Gaps:	134/610 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 NKKSGSNNEESSHL--LESAENGAKYGSRQPVKIVKASD-------NGRTSSTPHDQE----NLL 66
            |:|...|:   |||  :|:..|..::.|.:..:..|.||       .|..|..|:|..    :||
Yeast     9 NRKKDRND---SHLDEIENGVNATEFNSIEMEEQGKKSDFDLSHLEYGPGSLIPNDNNEEVPDLL 70

  Fly    67 GN-MVHTSTSNNSQKWPQYVAALAAAGGAFAAGTVLGWTSPAETEIVDRGEGYD---------FP 121
            .. |.....::.|::....:.||.....|.|      |:....|.::.  ||||         .|
Yeast    71 DEAMQDAKEADESERGMPLMTALKTYPKAAA------WSLLVSTTLIQ--EGYDTAILGAFYALP 127

  Fly   122 VDKDQFSWVGS---------AMTLGAACVCIPIGFLINM---------IGRKWTM---LFLVLPF 165
            |.:.::..:.|         :..:| .|:|...|.::.:         :|.::|:   ||.:..|
Yeast   128 VFQKKYGSLNSNTGDYEISVSWQIG-LCLCYMAGEIVGLQMTGPSVDYMGNRYTLIMALFFLAAF 191

  Fly   166 ILGWTMLIWAVNVSMLYASRFILGIAGGAF-CVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILF 229
            |.   :|.:..::.|:...:.:.|:..|.| |:|. .|..||....:|..|.::..|....|.||
Yeast   192 IF---ILYFCKSLGMIAVGQALCGMPWGCFQCLTV-SYASEICPLALRYYLTTYSNLCWAFGQLF 252

  Fly   230 V-----------------YAVGAGVKIFWLSIICGILPLIFGAIFFFMPESPTYLVSKDRSENAI 277
            .                 |.:...::..|      .|||..|  .||.||||.:||.|.|.:.|.
Yeast   253 AAGIMKNSQNKYANSELGYKLPFALQWIW------PLPLAVG--IFFAPESPWWLVKKGRIDQAR 309

  Fly   278 KSIQ-WLRGKEYDYE----PELAELRET-DRETK-ANKVNVWAALNRPVTRKALAISMGLMFFQQ 335
            :|:: .|.||..:.|    .||.:::.| ::|.| :::...|..:...:.|:...|:......|.
Yeast   310 RSLERTLSGKGPEKELLVSMELDKIKTTIEKEQKMSDEGTYWDCVKDGINRRRTRIACLCWIGQC 374

  Fly   336 VCGINAVIFYASRIFLEANTGIEAEWA---TILIGIMQVVATFVSTLVVDKLGRRILLLASGISM 397
            .||. ::|.|::..:.:|  |:..:.|   :|:...:.:.|||:|.......| |..|.|.|::.
Yeast   375 SCGA-SLIGYSTYFYEKA--GVSTDTAFTFSIIQYCLGIAATFISWWASKYCG-RFDLYAFGLAF 435

  Fly   398 AISTTAIGVYFFLQKQDAAQVVSLGWLPV--------ASLCLFIIMFSIGYGPVPWLMMGELFAT 454
            .      .:.||:       :..||....        |.|.:....:::|..||.:.::.|:.::
Yeast   436 Q------AIMFFI-------IGGLGCSDTHGAKMGSGALLMVVAFFYNLGIAPVVFCLVSEIPSS 487

  Fly   455 DIKGFAGSLAGTSNWLLAFVVTKTFV-NLND---GLGI-GGTFWLFAGLTVVGVIFVYFAVPETK 514
            .::.....||..:..::..|||...: .||.   ..|. .|.||  .|..:..:.:....:|||.
Yeast   488 RLRTKTIILARNAYNVIQVVVTVLIMYQLNSEKWNWGAKSGFFW--GGFCLATLAWAVVDLPETA 550

  Fly   515 GKSLNEIQQELAGNRSTPQAIPAEK 539
            |::..||      |......:||.|
Yeast   551 GRTFIEI------NELFRLGVPARK 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	92/422 (22%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	101/460 (22%)
MAL31	NP_009857.1	SP	74..557	CDD:273317	115/522 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342272
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830