DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10960 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_445946.2	Gene:	Slc2a8 / 85256	RGDID:	620611	Length:	478	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	166/463 - (35%)
Similarity:	261/463 - (56%)	Gaps:	31/463 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 YVAALAAAGGAFAAGTVLGWTSPAETEIVDRGEGYDFPVDKDQFSWVGSAMTLGAACVCIPIGFL 148
            ::|..|||.|..:.|..||::|||...: .|.......:.....||.|:.:|||||...:..|:|
  Rat    27 FLATFAAALGPLSFGFALGYSSPAIPSL-RRTAPPALRLGDTAASWFGAVVTLGAAAGGVLGGWL 90

  Fly   149 INMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLYASRFILGIAGGAFCVTAPMYTGEIAQKEIRG 213
            ::..|||.::|...:||:.|:.::..|.:|.||...|.:.|:|.|...:.||:|..|||...:||
  Rat    91 LDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRG 155

  Fly   214 TLGSFFQLMITIGILFVYAVGAGVKIFWLSIICGILPLIFGAIFFFMPESPTYLVSKDRSENAIK 278
            .|||..|||:..|||..|..|..::..||:::..:.|.:...:..:|||:|.:|:::.:.:.|:.
  Rat   156 LLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMA 220

  Fly   279 SIQWLRGKEYDYE--PELAELRETDRETKANKVNVWAALNRPVTRKALAISMGLMFFQQVCGINA 341
            ::::|.|.|..:|  |..||          ::....|.|.||...|.|.|.:.||.|||:.|:||
  Rat   221 ALRFLWGSEEGWEEPPVGAE----------HQGFQLAMLRRPGVHKPLIIGICLMVFQQLSGVNA 275

  Fly   342 VIFYASRIFLEANTGIEAEWATILIGIMQVVATFVSTLVVDKLGRRILLLASGISMAISTTAIGV 406
            ::|||:.||.||... ::..|::.:||:||:.|.|:.|::|:.||::||..||:.|..|.:|.|.
  Rat   276 IMFYANTIFEEAKFK-DSSLASVTVGIIQVLFTAVAALIMDRAGRKLLLALSGVIMVFSMSAFGT 339

  Fly   407 YFFLQKQ----------------DAAQV-VSLGWLPVASLCLFIIMFSIGYGPVPWLMMGELFAT 454
            ||.|.:.                :.|.| :.|.||.|.|:||||..|::|:||:|||:|.|:|..
  Rat   340 YFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPL 404

  Fly   455 DIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVGVIFVYFAVPETKGKSLN 519
            .|||.|..:...:||.:||:|||.|.::.:.|...|.|||.|...::.|:|....||||||::|.
  Rat   405 HIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFWLTAAFCILSVLFTLTFVPETKGRTLE 469

  Fly   520 EIQQELAG 527
            :|.....|
  Rat   470 QITAHFEG 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	132/375 (35%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	145/408 (36%)
Slc2a8	NP_445946.2	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:10671487	12..13
		MFS	27..470	CDD:421695	164/454 (36%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337685
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52445
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		otm45904
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.760