DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10960 and VVS1

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_009800.1	Gene:	VVS1 / 852543	SGDID:	S000000445	Length:	488	Species:	Saccharomyces cerevisiae

Alignment Length:	527	Identity:	144/527 - (27%)
Similarity:	228/527 - (43%)	Gaps:	100/527 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 NGAKYGSRQPVKIVKASDNGRTSSTPHDQENLLGNMVHTSTSNNSQKWPQYVAALAAAGGAFAAG 98
            ||   |||:...::          |.|   .:||.:|   ....|.::..::|.|.|
Yeast    10 NG---GSRETKPLI----------TGH---LILGTIV---ACLGSIQYGYHIAELNA-------- 47

  Fly    99 TVLGWTSPAETEIVDRGEGYDFPVDKDQFSWVGS-------AMT---LGAACVCIPIGFLI---- 149
                   |.|.....|.|..|..:..|. :|||.       |:|   .||......||.|.
Yeast    48 -------PQEFLSCSRFEAPDENISYDD-TWVGQHGLKQCIALTDSQYGAITSIFSIGGLFGSYY 104

  Fly   150 -----NMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLYASRFILGIAGGAFCVTAPMYTGEIAQK 209
                 |..|||:..:......::...:|.::.:...|...||::|::.|...|..|::..|||..
Yeast   105 AGNWANRYGRKYVSMGASAMCMVSSLLLFFSNSYLQLLFGRFLVGMSCGTAIVITPLFINEIAPV 169

  Fly   210 EIRGTLGSFFQLMITIGILFV------YAVGAGVKIFWLSIICGILPLIFGAIFFFMPESPTYLV 268
            |.||.:||..|:.|.:|||..      ||.....:  ||.....::.:.....:..:.|||.:||
Yeast   170 EWRGAMGSMNQVSINLGILLTQTLALKYADSYNWR--WLLFSGSVIAVANILAWLKVDESPRWLV 232

  Fly   269 SK---DRSENAI------------KSIQ-WLRGKEYDYEPELAELRETDRETKANKVNVWAALNR 317
            |.   ..:|.|:            :.|| |.|...::.:||.:|      ||.:.. .:|..:..
Yeast   233 SHGFVSEAETALFKLRPGTYQQAKQEIQDWQRSHGHNRDPESSE------ETHSGP-TLWQYVTD 290

  Fly   318 PVTRKALAISMGLMFFQQVCGINAVIFYASRIF--LEANTGIEAEWATILIGIMQVVATFVSTLV 380
            |..:|...:.:.::..||.||||::|||..::.  :..:..|:..:|   |.|:.||.|..::.:
Yeast   291 PSYKKPRTVILAILSCQQFCGINSIIFYGVKVIGKILPDYSIQVNFA---ISILNVVVTLAASAI 352

  Fly   381 VDKLGRRILLLASGISMAISTTAIGVYFFLQKQDAAQVVSLGWLPVASLCLFIIMFSIGYGPVPW 445
            :|.:|||.|||||...|...:..|.|         ...:|:.:|.|.:..::|..|:||.||:|:
Yeast   353 IDHVGRRPLLLASTTVMTAMSLLISV---------GLTLSVSFLLVTATFVYIAAFAIGLGPIPF 408

  Fly   446 LMMGELFATDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVGVIFVYFAV 510
            |::|||........|.|.....|||..|:|...| .:..||..|..|.:||.:..:...:||..|
Yeast   409 LIIGELSYPQDAATAQSFGTVCNWLATFIVGYLF-PIGHGLMGGYVFAIFAAIAAMFATYVYKRV 472

  Fly   511 PETKGKS 517
            ||||||:
Yeast   473 PETKGKT 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	108/399 (27%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	118/432 (27%)
VVS1	NP_009800.1	MFS_GLUT_Class1_2_like	28..478	CDD:340915	133/490 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342265
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.740