DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10960 and CIN10

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_010675.3	Gene:	CIN10 / 851995	SGDID:	S000002795	Length:	555	Species:	Saccharomyces cerevisiae

Alignment Length:	542	Identity:	136/542 - (25%)
Similarity:	222/542 - (40%)	Gaps:	110/542 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 NMVHTSTSNNSQKWPQYVAALAAA---GGAFAAGTVLGWTSPAETEIVD------RGEGYDFPVD 123
            :.|.::|:|:.::.| |......:   .||...|.:.|:    :|.::.      :.|.....|.
Yeast    18 SQVTSNTANDIEQLP-YALTFKTSLIFVGATIGGLLFGY----DTGVISGVLLSLKPEDLSLVVL 77

  Fly   124 KD-QFSWVGSAMTLGA---ACVCIPIGFLINMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLYAS 184
            .| |...:.|:.::|:   :.:..|   |.:..||:.|:......|||....:..|..::.|...
Yeast    78 TDVQKELITSSTSVGSFFGSILAFP---LADRYGRRITLAICCSIFILAAIGMAIARTLTFLICG 139

  Fly   185 RFILGIAGGAFCVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVK--------IFW 241
            |.::|||.|......|::..||:...|||.:.:...:.||.|.|..|.:.:.:|        :|.
Yeast   140 RLLVGIAVGVSAQCVPLFLSEISPSRIRGFMLTLNIIAITGGQLVSYVIASLMKEIDNSWRYLFA 204

  Fly   242 LSIICGILPLIFGAIFFFMPESPTYLVSK-----------------------DRSENAIKSIQWL 283
            ||.|..||   |.:|..|:||||.:.:||                       .:.:..|..:..|
Yeast   205 LSAIPAIL---FLSILDFIPESPRWSISKGDILYTRDSLRMLYPTASTYHVNSKIKQLIIELDKL 266

  Fly   284 RGKEYDYEPELAE----LRETDRETK------------------ANKV---------------NV 311
            |..|...||.|.:    :|..|..|.                  :|.:               |.
Yeast   267 RLYEDASEPLLVQSQSVIRYMDSSTSGTLSPPNIKRLSSNTERTSNTMSSSSAYLSALRGPAPNG 331

  Fly   312 WAALNR-------PVTRKALAISMGLMFFQQVCGINAVIFYASRIFLEANTGIEAEWATILIGIM 369
            ..|.|:       |.|.:||.:...||||||:.|.||.::||:.||.:.|.. ......|||...
Yeast   332 ALASNKKKRHRMEPRTIRALIVGCMLMFFQQITGFNAFMYYAAIIFSKFNIK-NPLLPPILIAST 395

  Fly   370 QVVATFVSTLVVDKLGRRILLLASGISMAISTTAIGVYFFLQKQDAAQVVSLGWLPVASLCLFII 434
            ..:.||.:...:|.||||.:||.:.:.|.:......|.|   ..|...::      :.|:.:::.
Yeast   396 NFIFTFFAMYTMDSLGRRAILLRTILIMTVGLLLCSVGF---GHDQVNLL------LISVVIYVA 451

  Fly   435 MFSIGYGPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLT 499
            .::...|.|||..: |....:.:.|..|....:|||....|:.|:::..:.:|...|..:||..|
Yeast   452 AYASAMGSVPWTCV-EFLPLNRRSFGASCIACTNWLTNAFVSMTYLSTINTIGDENTMLIFAFFT 515

  Fly   500 VVGVIFVYFAVPETKGKSLNEI 521
            |....||||..||.||.||.|:
Yeast   516 VCAWFFVYFWYPEVKGLSLEEV 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	106/435 (24%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	116/468 (25%)
CIN10	NP_010675.3	MFS_HMIT_like	45..528	CDD:340918	124/503 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13428
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	5	4.740