DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10960 and SNF3

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_010087.1	Gene:	SNF3 / 851333	SGDID:	S000002353	Length:	884	Species:	Saccharomyces cerevisiae

Alignment Length:	574	Identity:	150/574 - (26%)
Similarity:	243/574 - (42%)	Gaps:	94/574 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NNEESSHLLESAENGAKYGSRQPVKIVKASDNGRTSSTPHDQENLLGNMVHTSTS---NNSQKW- 81
            |:..||..|...:.|....:.|.||.:....|  .|:..|..::..|: :.|.||   .||.:.
Yeast     4 NSNSSSETLRQEKQGFLDKALQRVKGIALRRN--NSNKDHTTDDTTGS-IRTPTSLQRQNSDRQS 65

  Fly    82 -----------------------PQ--------YVAALAAAGG---AFAAGTVLGWTSP--AETE 110
                                   ||        .|....|.||   .:..|.:...||.  .::.
Yeast    66 NMTSVFTDDISTIDDNSILFSEPPQKQSMMMSICVGVFVAVGGFLFGYDTGLINSITSMNYVKSH 130

  Fly   111 IVDRGEGYDFPVDKDQFSWVGSAMTLGAACVCIPIGFLINMIGRKWTMLF-LVLPFILGWTMLIW 174
            :....:.:    ...|.|.:.|.::||.....:...|:.:..|||.|::| .:..|.:|.::.:.
Yeast   131 VAPNHDSF----TAQQMSILVSFLSLGTFFGALTAPFISDSYGRKPTIIFSTIFIFSIGNSLQVG 191

  Fly   175 AVNVSMLYASRFILGIAGGAFCVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILF---------- 229
            |..:::|...|.|.||..||.....|:|..|...|.:||.:.|.:|..||.|:|.
Yeast   192 AGGITLLIVGRVISGIGIGAISAVVPLYQAEATHKSLRGAIISTYQWAITWGLLVSSAVSQGTHA 256

  Fly   230 -----VYAVGAGVKIFWLSIICGILPLIFGAI-FFFMPESPTYLVSKDRSENAIKSIQWLRG--- 285
                 .|.:..|::..|.|         |.|| .||:||||.|.|.||:.:.|.||:.:|||
Yeast   257 RNDASSYRIPIGLQYVWSS---------FLAIGMFFLPESPRYYVLKDKLDEAAKSLSFLRGVPV 312

  Fly   286 KEYDYEPELAELRET-DRET---KANKVNVW-AALNRPVTRKALAISMGLMFFQQVCGINAVIFY 345
            .:.....||.|::.| |.|.   .:|.::.: ::.:||.....:...:.|..|||..|||.:.:|
Yeast   313 HDSGLLEELVEIKATYDYEASFGSSNFIDCFISSKSRPKQTLRMFTGIALQAFQQFSGINFIFYY 377

  Fly   346 ASRIFLEANTGIEAEW-ATILIGIMQVVATFVSTLVVDKLGRRILLLASGISMAISTTAIGVYFF 409
            ....|  ..||:...: .:.:...:.||........|:..|||.:|:..|:.|.|:...:.:...
Yeast   378 GVNFF--NKTGVSNSYLVSFITYAVNVVFNVPGLFFVEFFGRRKVLVVGGVIMTIANFIVAIVGC 440

  Fly   410 LQKQDAAQVVSLGWLPVASLCLFIIMFSIGYGPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFV 474
            ..|..||..|.     :|.:||||..||..:|.|.|::..||:...::....::...:|||:.|:
Yeast   441 SLKTVAAAKVM-----IAFICLFIAAFSATWGGVVWVISAELYPLGVRSKCTAICAAANWLVNFI 500

  Fly   475 ---VTKTFVNLNDGLGIGGT--FWLFAGLTVVGVIFVYFAVPETKGKSLNEIQQ 523
               :|...|:........|.  |:::..|..:|||.||..|.||||.:|.||.:
Yeast   501 CALITPYIVDTGSHTSSLGAKIFFIWGSLNAMGVIVVYLTVYETKGLTLEEIDE 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	105/382 (27%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	115/420 (27%)
SNF3	NP_010087.1	MFS_HXT	99..556	CDD:340914	131/476 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342259
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I1031
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13432
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	8	7.690