DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10960 and HXT10

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_116644.1	Gene:	HXT10 / 850536	SGDID:	S000001883	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	515	Identity:	146/515 - (28%)
Similarity:	237/515 - (46%)	Gaps:	90/515 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 WPQYVAALAAAGGAFA----AGTVLGWTSPAETEIVDR-GEGYDFPVDKD---QFSWVGSAM--- 134
            |......|..|.|.|.    .||:.|:.:  :|:...| ||     :.:|   |.|.|.:.:
Yeast    47 WTVMGLCLMIAFGGFIFGWDTGTISGFIN--QTDFKRRFGE-----LQRDGSFQLSDVRTGLIVG 104

  Fly   135 --TLGAACVCIPIGFLINMIGRKWTMLFLVLPFILGWTMLI-----WAVNVSMLYASRFILGIAG 192
              .:|.|...:.:|.|.::.|||..::.::|.:::|..:.|     |    ...:..|.:.|:..
Yeast   105 IFNIGCALGGLTLGRLGDIYGRKIGLMCVILVYVVGIVIQIASSDKW----YQYFIGRIVSGMGV 165

  Fly   193 GAFCVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVKIFWLSIICGI-LPLIFG-A 255
            |...|.:|....||:.|.:|||..||:|||||:||...|....|.|.:..||...: |.|.|. |
Yeast   166 GGVAVLSPTLISEISPKHLRGTCVSFYQLMITLGIFLGYCTNYGTKKYSNSIQWRVPLGLCFAWA 230

  Fly   256 IFF-----FMPESPTYLVSKDRSENAIKSIQWLR-------GKEYDYEPELAELRETDR------ 302
            ||.     .:||||.|||.|.:.|.|.:|:....       |..::::..:|.: |.:|
Yeast   231 IFMVIGMVMVPESPRYLVEKGKYEEARRSLAKSNKVTVTDPGVVFEFDTIVANM-ELERAVGNAS 294

  Fly   303 --ETKANKVNVWAALNRPVTRKALAISMGLMF--FQQVCGINAVIFYASRIFLEANTGIEAEWAT 363
              |..:||   .|.|.|        :.||::.  .||:.|.|...:|.:.||  ...|::..:.|
Yeast   295 WHELFSNK---GAILPR--------VIMGIVIQSLQQLTGCNYFFYYGTTIF--NAVGMQDSFET 346

  Fly   364 -ILIGIMQVVATFVSTLVVDKLGRRILLLASGISMAIS---TTAIGV-YFFLQKQDAAQVVSLGW 423
             |::|.:...:|||:..:|||.|||..||....||||.   ...:|| ..:.|.:|.....|.|.
Yeast   347 SIVLGAVNFASTFVALYIVDKFGRRKCLLWGSASMAICFVIFATVGVTRLWPQGKDQPSSQSAGN 411

  Fly   424 LPVASLCLFIIMFSIGYGPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVV--TKTFVNLNDGL 486
            :.:...|.||..|:|.:.|:.::::.|.:...:|..|.::|..:||:..|::  ...|:..:.|.
Yeast   412 VMIVFTCFFIFSFAITWAPIAYVIVAETYPLRVKNRAMAIAVGANWMWGFLIGFFTPFITRSIGF 476

  Fly   487 GIGGTFWLFAGLTVVGVIFVYFAVPETKGKSL---NEIQQE----------LAGNRSTPQ 533
            ..|   ::|.|..:....:|:|.|.||||.:|   ||:.:|          :..:|.|||
Yeast   477 SYG---YVFMGCLIFSYFYVFFFVCETKGLTLEEVNEMYEERIKPWKSGGWIPSSRRTPQ 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	113/398 (28%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	120/433 (28%)
HXT10	NP_116644.1	Sugar_tr	52..512	CDD:395036	140/487 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342296
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13432
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	7	6.640