Protein Alignment nebu and SLC2A5

DIOPT Version :10

• Sequence 1: NP_648605.1
• Gene: nebu / 39458
• FlyBaseID: FBgn0036316
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_003030.1
• Gene: SLC2A5 / 6518
• HGNCID: 11010
• Length: 501
• Species: Homo sapiens
• Alignment Length: 490
• Identity: 150/490 - (30%)
• Similarity: 239/490 - (48%)
• Gaps: 61/490 - (12%)

  Fly    88 LAAAGGAFAAG-TVLGWTSPA--------ETEIVDRGEGY-DFPVDKDQFSWVGSAMTLGAACVC 142
            :||.|.:|..| .|....|||        ||.....||.. |||:.. .:|...|....|.....
Human    23 IAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTL-LWSVTVSMFPFGGFIGS 86

  Fly   143 IPIGFLINMIGRKWTMLF-----LVLPFILGWTMLIWAVNVSMLYASRFILGIAGGAFCVTAPMY 202
            :.:|.|:|..|||..:||     :|...::|.:.:  |.:..::..||.::||..|......|||
Human    87 LLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRV--ATSFELIIISRLLVGICAGVSSNVVPMY 149

  Fly   203 TGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVKIFWL-SIICGI--LPLIFG---------- 254
            .||:|.|.:||.||...||.||:|||.       .:||.| :::..:  .|::.|
Human   150 LGELAPKNLRGALGVVPQLFITVGILV-------AQIFGLRNLLANVDGWPILLGLTGVPAALQL 207

  Fly   255 AIFFFMPESPTYLVSKDRSENAI-KSIQWLRGKEYDYEPELAELRETDR-ETKANKVNVWAALNR 317
            .:..|.||||.||:.:.:.|.|. |::|.|||.: ..:.|:||:|:.|. |..|..::|......
Human   208 LLLPFFPESPRYLLIQKKDEAAAKKALQTLRGWD-SVDREVAEIRQEDEAEKAAGFISVLKLFRM 271

  Fly   318 PVTRKALAISMGLMFFQQVCGINAVIFYASRIFLEANTGIE-AEWATILIGIMQVVATFVSTLVV 381
            ...|..|...:.||..||:.|:||:.:||.:|:|.|....| .::.|...|.:.||.||.:..||
Human   272 RSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVV 336

  Fly   382 DKLGRRILLLASG----ISMAISTTAIGVYFFLQKQDAAQVVSLGWLPVASL-CL--FIIMFSIG 439
            :.||||:|||...    |:..:.|.|:.:      ||     ::.|:|..|: |:  ::|..::|
Human   337 ELLGRRLLLLLGFSICLIACCVLTAALAL------QD-----TVSWMPYISIVCVISYVIGHALG 390

  Fly   440 YGPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVGVI 504
            ..|:|.|::.|:|....:..|..:.|:.:||..|.|...|..:.:||| ..:|.:||.:.::..|
Human   391 PSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLG-PYSFIVFAVICLLTTI 454

  Fly   505 FVYFAVPETKGKSLNEIQQELAGNRSTPQAIPAEK 539
            :::..|||||.|:..||.|.........:..|.::
Human   455 YIFLIVPETKAKTFIEINQIFTKMNKVSEVYPEKE 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nebu	NP_648605.1	MFS_GLUT6_8_Class3_like	99..520	CDD:340916	141/457 (31%)
SLC2A5	NP_003030.1	MFS_GLUT_Class2	23..471	CDD:340990	146/470 (31%)