Protein Alignment nebu and SLC2A3

DIOPT Version :10

• Sequence 1: NP_648605.1
• Gene: nebu / 39458
• FlyBaseID: FBgn0036316
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 126/412 - (30%)
• Similarity: 207/412 - (50%)
• Gaps: 34/412 - (8%)

  Fly   135 TLGAACVCIPIGFLINMIGRKWTMLFLVLPFILGWTML---IWAVNVSMLYASRFILGIAGGAFC 196
            ::|.......:|..:|..||:.:||.:.|..:.|...:   ..|.:|.||...|.::|:..|...
Human    71 SVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCT 135

  Fly   197 VTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVKIFWLSIICG---ILPLIFG---- 254
            ...|||.|||:...:||..|:..||.|.:|||.       .:||.|..|.|   :.||:.|
Human   136 GFVPMYIGEISPTALRGAFGTLNQLGIVVGILV-------AQIFGLEFILGSEELWPLLLGFTIL 193

  Fly   255 ------AIFFFMPESPTY-LVSKDRSENAIKSIQWLRGKEYDYEPELAELR-ETDRETKANKVNV 311
                  |...|.||||.: |:::...|||.:.:|.|.|.: |...::.|:: |:.|.::..:|.|
Human   194 PAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQ-DVSQDIQEMKDESARMSQEKQVTV 257

  Fly   312 WAALNRPVTRKALAISMGLMFFQQVCGINAVIFYASRIFLEANTGI-EAEWATILIGIMQVVATF 375
            .........|:.:.||:.|...||:.|||||.:|::.||.:|  |: |..:|||..|::..:.|.
Human   258 LELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDA--GVQEPIYATIGAGVVNTIFTV 320

  Fly   376 VSTLVVDKLGRRILLLASGISMAISTTAIGVYFFLQKQDAAQVVSLGWLPVASLCLFIIMFSIGY 440
            ||..:|::.|||.|.:.....||..:|.:.|...|:.    ....:.::.:.::.:|:..|.||.
Human   321 VSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKD----NYNGMSFVCIGAILVFVAFFEIGP 381

  Fly   441 GPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVGVIF 505
            ||:||.::.|||:...:..|.::||.|||...|:|...|.:....|| ...|.:|.|..:..:.|
Human   382 GPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLG-AYVFIIFTGFLITFLAF 445

  Fly   506 VYFAVPETKGKSLNEIQQELAG 527
            .:|.||||:|::..:|.:...|
Human   446 TFFKVPETRGRTFEDITRAFEG 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nebu	NP_648605.1	MFS_GLUT6_8_Class3_like	99..520	CDD:340916	124/403 (31%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	123/399 (31%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)