Protein Alignment CG10960 and SLC2A3

DIOPT Version :9

• Sequence 1: NP_648605.1
• Gene: CG10960 / 39458
• FlyBaseID: FBgn0036316
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 126/412 - (30%)
• Similarity: 207/412 - (50%)
• Gaps: 34/412 - (8%)

  Fly   135 TLGAACVCIPIGFLINMIGRKWTMLFLVLPFILGWTML---IWAVNVSMLYASRFILGIAGGAFC 196
            ::|.......:|..:|..||:.:||.:.|..:.|...:   ..|.:|.||...|.::|:..|...
Human    71 SVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCT 135

  Fly   197 VTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVKIFWLSIICG---ILPLIFG---- 254
            ...|||.|||:...:||..|:..||.|.:|||.       .:||.|..|.|   :.||:.|
Human   136 GFVPMYIGEISPTALRGAFGTLNQLGIVVGILV-------AQIFGLEFILGSEELWPLLLGFTIL 193

  Fly   255 ------AIFFFMPESPTY-LVSKDRSENAIKSIQWLRGKEYDYEPELAELR-ETDRETKANKVNV 311
                  |...|.||||.: |:::...|||.:.:|.|.|.: |...::.|:: |:.|.::..:|.|
Human   194 PAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQ-DVSQDIQEMKDESARMSQEKQVTV 257

  Fly   312 WAALNRPVTRKALAISMGLMFFQQVCGINAVIFYASRIFLEANTGI-EAEWATILIGIMQVVATF 375
            .........|:.:.||:.|...||:.|||||.:|::.||.:|  |: |..:|||..|::..:.|.
Human   258 LELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDA--GVQEPIYATIGAGVVNTIFTV 320

  Fly   376 VSTLVVDKLGRRILLLASGISMAISTTAIGVYFFLQKQDAAQVVSLGWLPVASLCLFIIMFSIGY 440
            ||..:|::.|||.|.:.....||..:|.:.|...|:.    ....:.::.:.::.:|:..|.||.
Human   321 VSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKD----NYNGMSFVCIGAILVFVAFFEIGP 381

  Fly   441 GPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVGVIF 505
            ||:||.::.|||:...:..|.::||.|||...|:|...|.:....|| ...|.:|.|..:..:.|
Human   382 GPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLG-AYVFIIFTGFLITFLAF 445

  Fly   506 VYFAVPETKGKSLNEIQQELAG 527
            .:|.||||:|::..:|.:...|
Human   446 TFFKVPETRGRTFEDITRAFEG 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	109/357 (31%)
		MFS	118..508	CDD:119392	118/391 (30%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	123/399 (31%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)
		Monosaccharide binding. /evidence=ECO:0000269|PubMed:26176916	280..286		3/5 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143892
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740