DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10960 and slc2a6

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_689092.6	Gene:	slc2a6 / 560602	ZFINID:	ZDB-GENE-081104-301	Length:	490	Species:	Danio rerio

Alignment Length:	483	Identity:	148/483 - (30%)
Similarity:	239/483 - (49%)	Gaps:	31/483 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 TSTSNNSQKWPQ------YVAALAAAGGAFAAGTVLGWTSPAETEIVDRGEGYDFPVDKDQFSWV 130
            |...|||.  |:      |:|..:|..|.|..|..|.:.||...:: .:|:.....::..|.||.
Zfish     9 TPLINNSP--PRISHGKLYLAVFSAVLGNFNFGFALVFPSPVIPQL-KQGDDTRLQMNVHQISWF 70

  Fly   131 GSAMTLGAACVCIPIGFLINMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLYASRFILGIAGGAF 195
            ||..|||||...:...||.:.:|||.:::...||.:||..::..|.|..||...||:.|||||..
Zfish    71 GSIFTLGAAAGGLSAMFLNDRVGRKISIMISGLPSVLGLLVMGSAQNFWMLLWGRFLTGIAGGIT 135

  Fly   196 CVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVKIFWLSIICGILPLIFGAIFFFM 260
            ..:.|:|..||:...:||.|||..|:....|.|.:||.|..:...||::...:..:|...:...|
Zfish   136 AGSIPVYVSEISHPSVRGALGSCPQITAVFGSLALYAFGLILPWRWLAVAGEVPVVIMMLLLCCM 200

  Fly   261 PESPTYLVSKDRSENAIKSIQWLRGKEYDYEPELAELRETDRETKANKVNVWAALNRPVTRKALA 325
            |.||.|.:.|.....|:||::||||...||   :.|..:.:|......|. |:.|......|.:.
Zfish   201 PTSPRYHIMKGNRAKAVKSLEWLRGPNSDY---MTEFNKIERSITTQGVQ-WSDLKTKSYYKPIL 261

  Fly   326 ISMGLMFFQQVCGINAVIFYASRIFLEANTGIEAEWATILIGIMQVVATFVSTLVVDKLGRRILL 390
            ||:.:.|.||:.||..::.|...||......:|.::...|:|.:::::..::..::||.||:.||
Zfish   262 ISVVMRFLQQMTGITPILVYLEPIFHLTAISLEPKYDAALVGAVRLISVAIAASLMDKAGRKALL 326

  Fly   391 LASGISMAISTTAIGVYFF--------LQKQDAAQV---VSLG-------WLPVASLCLFIIMFS 437
            ..||..:.|:..::.:|..        |...|...:   |..|       .:|:.|..:.|..::
Zfish   327 FTSGFLIYIAMLSMTMYTHQTPCSQGNLTLTDGLNISSEVQAGAAFDPKTLIPLISAMVIIFGYA 391

  Fly   438 IGYGPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVG 502
            :|:||:.||:|.|:.....:|.|..|....:|:.|||:|:.|:::....|:...|..|..::||.
Zfish   392 MGWGPITWLLMSEILPLGARGVASGLCVGVSWITAFVLTQLFMHVVVAYGLYVPFLFFCVVSVVN 456

  Fly   503 VIFVYFAVPETKGKSLNEIQQELAGNRS 530
            :||....||||||::|.||:......||
Zfish   457 IIFTAKCVPETKGRTLEEIENYFRTGRS 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	111/374 (30%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	122/407 (30%)
slc2a6	XP_689092.6	Sugar_tr	27..479	CDD:278511	140/456 (31%)
slc2a6	XP_689092.6	MFS	28..461	CDD:119392	130/437 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576881
Domainoid	1	1.000	292	1.000	Domainoid score	I1492
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2576
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm6527
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.800