DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10960 and Slc2a12

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_849265.2	Gene:	Slc2a12 / 353169	MGIID:	3052471	Length:	622	Species:	Mus musculus

Alignment Length:	539	Identity:	137/539 - (25%)
Similarity:	239/539 - (44%)	Gaps:	109/539 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 YVAALAAAGGAFAAGTVLGWTSPAETEIVDRGEGYDFPVDKDQFSWVGSAMTLGAACVCIPIGFL 148
            ::.::.||......|..||..|.|..:|...     ..:...:...|.|::.:||....:..|.|
Mouse    45 FLTSVTAAISGLLVGYELGLISGALLQIRTL-----LALTCHEQEMVVSSLLIGAFLASLTGGVL 104

  Fly   149 INMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLYASRFILGIAGGAFCVTAPMYTGEIAQKEIRG 213
            |:..||:..::.......||..:||.:::.::|...|..:|::.....:...:|..|||.:..||
Mouse   105 IDRYGRRLAIILSSCLLGLGSLVLIMSLSYTLLIMGRVAIGVSISLSSIATCVYIAEIAPQHRRG 169

  Fly   214 TLGSFFQLMITIGILFVYA-------VGAGVK-IFWLSIICGILPLIFGAIFFFMPESPTYLVSK 270
            .|.|..:|||..||||.|.       :..|.| :|.|.|..|:|..|   ..:|:|.||.:||.|
Mouse   170 LLVSLNELMIVTGILFAYISNYAFANISNGWKYMFGLVIPLGVLQAI---AMYFLPPSPRFLVMK 231

  Fly   271 DRSENAIKSIQWLRGKEYDYEPELAELRETDRETKANKVNVWAAL-NRPVTRKALAISMGLMFFQ 334
            .:.|:|.|.::.||... |...||..::.:.::  ..:.:.|... ::...|..:.|.:.|:||.
Mouse   232 GQEESAGKVLRKLRVIS-DTTEELTLIKSSLKD--EYQYSFWDLFRSKDNMRTRILIGLTLVFFV 293

  Fly   335 QVCGINAVIFYASRIFLEANTGIEAEWATIL----IGIMQVVATFVSTLVVDKLGRRIL------ 389
            |..|...::||||.:.  .:.|.::..|..|    :|:::||:|..:||:||.:|.:..
Mouse   294 QTTGQPNILFYASTVL--KSVGFQSNEAASLASTGVGVVKVVSTIPATLLVDHIGSKTFLCIGSS 356

  Fly   390 -----LLASGI--------------------------------SMAISTTAIGVYF--------- 408
                 ||..||                                :::||.:::..:|
Mouse   357 VMSASLLTMGIVNLNINMNFTNICRSHSLLNQSLEEFVFYATGNLSISNSSLREHFKRITPYSKG 421

  Fly   409 -FLQK-----------------------------QDAAQV-VSLGWLPVASLCLFIIMFSIGYGP 442
             |:..                             .|.|.| .:..||.:|||.:::..||||.||
Mouse   422 SFMPMGNGMEPKGEMTFTSSLPNAGLSRTEHQGVTDTAVVPAAYKWLSLASLLVYVAAFSIGLGP 486

  Fly   443 VPWLMMGELFATDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVGVIFVY 507
            :|||::.|:|...|:|.|.:|..:.||.:..:::.||:.:.|.:|:....:::..:::..:.||.
Mouse   487 MPWLVLSEIFPGGIRGRAMALTSSMNWGVNLLISLTFLTVTDLIGLSWVCFIYTIMSLASLAFVV 551

  Fly   508 FAVPETKGKSLNEIQQELA 526
            ..:|||||.||.:|..|||
Mouse   552 LFIPETKGCSLEQISVELA 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	112/452 (25%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	118/485 (24%)
Slc2a12	NP_849265.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Sugar_tr	48..569	CDD:278511	134/533 (25%)
		MFS	49..>367	CDD:119392	89/330 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840