DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10960 and itr1

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_593858.2	Gene:	itr1 / 2543145	PomBaseID:	SPAC4F8.15	Length:	575	Species:	Schizosaccharomyces pombe

Alignment Length:	555	Identity:	143/555 - (25%)
Similarity:	237/555 - (42%)	Gaps:	81/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ANKKS---GSNNEESSHLLESAENGAKYGSRQPVKIVKASDNGRTS--------STPHDQENLLG 67
            |:|||   .|..|..:.:|             ||..|....||..|        |.||...:
pombe    28 ADKKSPFESSVFENKTQVL-------------PVDSVSRLSNGARSRSNSNISLSEPHALND--- 76

  Fly    68 NMVHTSTSNNSQKWPQYVAALAAAGG---AFAAGTVLG-----WTSPAETEIVDRGEGYDFPVDK 124
                |.......||...:|..|..||   .:..|.:.|     .||....|:.:.|:
pombe    77 ----TVEDQPVSKWVWVLAFAAGIGGLLFGYDTGVISGALVVIGTSLGGHELTNGGK-------- 129

  Fly   125 DQFSWVGSAMTLGAACVCIPIGFLINMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLYASRFILG 189
               .::.||.:|||....|..|.|.:..|||..:....:..|:|..:.:.|.::..:...||::|
pombe   130 ---EFITSATSLGALLGGIIAGALADFFGRKPVIAIASIIIIVGSIVQVTAHHLWHMIVGRFVIG 191

  Fly   190 IAGGAFCVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVKIF-----WLSIICGIL 249
            ...|...:..|:|..|||..:|||.|...:.|:||.|.:..|.:....:..     |: :...::
pombe   192 WGVGIASLIIPLYLSEIAPSKIRGRLVIIYVLLITAGQVIAYGIDTAFEHVHNGWRWM-VGLAMV 255

  Fly   250 PLIFGA-IFFFMPESPTYLVSKDRSENAIKSIQWLRGKEYDYE--PELAELRETDRETKANKVNV 311
            |..|.. |..::||||..||.|:||:.|..::..:....:.||  .:|..::|..|:..:.  :.
pombe   256 PAAFQLFILIWLPESPRLLVKKERSQEAYNTLARIYPTAHPYEIKTKLYLIQEGVRDPFSG--SR 318

  Fly   312 WAALNR--------PVTRKALAISMGLMFFQQVCGINAVIFYASRIFLEANTGIEAEWAT-ILIG 367
            |..:.:        |...:||.::.||...||:.|.|::::::|.||  ...|.....|| ::|.
pombe   319 WQKIVKTFKELYFNPSNFRALILACGLQAMQQLSGFNSLMYFSSTIF--EVVGFNNPTATGLIIA 381

  Fly   368 IMQVVATFVSTLVVDKLGRRILLLAS--GISMAISTTAIGVYFFLQKQDAAQVV---SLGWLPVA 427
            ....|.|.|:..|:|..|||||||.:  |:..|:...|: .:.||.|.:.....   |..|..|.
pombe   382 ATNFVFTIVAFGVIDFFGRRILLLLTVWGMIAALIVCAV-AFHFLPKDENGNYTSGQSNAWAIVV 445

  Fly   428 --SLCLFIIMFSIGYGPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGG 490
              |:.:::..::.|.|.:|| ...|||...::|....::...||.....:..:|:.|...:...|
pombe   446 LISMIVYVASYASGLGNLPW-QQSELFPMSVRGLGTGMSTAVNWAGNLGIGASFLTLMSEITPTG 509

  Fly   491 TFWLFAGLTVVGVIFVYFAVPETKGKSLNEIQQEL 525
            ||.|:.||..:|.:...|..|:....::.||.:.|
pombe   510 TFALYGGLCFLGWLGALFCYPDLTDYTIEEIGELL 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	100/380 (26%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	109/413 (26%)
itr1	NP_593858.2	Sugar_tr	90..544	CDD:278511	123/471 (26%)
itr1	NP_593858.2	MFS	92..529	CDD:119392	119/454 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	184	1.000	Inparanoid score	I1095
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13833
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860