DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10960 and itr2

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_593320.1	Gene:	itr2 / 2541827	PomBaseID:	SPAC20G8.03	Length:	557	Species:	Schizosaccharomyces pombe

Alignment Length:	552	Identity:	140/552 - (25%)
Similarity:	248/552 - (44%)	Gaps:	52/552 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTASSSNSSGEEANKKSGSNNEESSHLLESAENGAKYGSRQPVKIVKASDNGRTSSTPHDQE-N 64
            ::|..||:..|::...:..:...|:..                 |:..:.|.....|.|:::| |
pombe     8 LATIKSSDDKGKDFIVEMTTRPSETKK-----------------KVPFSEDMREIPSLPNEEEAN 55

  Fly    65 LLGNMVHTSTSNN-----SQKWPQYVAALAAAGGAFAAGTVLGW-TSPAETEIVDRGEGYDFPVD 123
            ......:.....|     ::|...::..|:|..|  .:|.:.|: |......:...|......:.
pombe    56 ATDPQANEVADENGEGFEAEKISSWIWVLSAVAG--ISGLLFGYDTGVISGALAVLGSDLGHVLS 118

  Fly   124 KDQFSWVGSAMTLGAACVCIPIGFLINMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLYASRFIL 188
            ..|...:.||.:..|.......|:|.:.:|||..:|.....|::|..::..:.||:|:...|||:
pombe   119 SGQKELITSATSFAALISATTSGWLADWVGRKRLLLCADAIFVIGSVIMAASRNVAMMVVGRFIV 183

  Fly   189 GIAGGAFCVTAPMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAG---VKIFWLSIICGI-- 248
            |...|...:..|||..|:|...:||.|...:.:.||.|.|..|::.|.   |...| .|:.||
pombe   184 GYGIGLTSLIVPMYITELAPARLRGRLVIIYVVFITGGQLIAYSLNAAFEHVHQGW-RIMFGIGA 247

  Fly   249 LPLIFGAI-FFFMPESPTYLVSKDRSENAIKSIQWL----RGKEYDYEPELAELRETDRETKANK 308
            .|.:...| .|:.||||.||:..:..|...|.:..:    :..|..|:..|.:........:.||
pombe   248 APALGQLISLFWTPESPRYLLRHNHVEKVYKILSRIHPEAKPAEIAYKVSLIQEGVKVDFPEGNK 312

  Fly   309 V-----NVWAALNRPVTRKALAISMGLMFFQQVCGINAVIFYASRIFLEANTGIEAEWA-TILIG 367
            .     ::......|..|::|.|...|.:|||..|.||:.::::.||  .:.|.:...: :|::|
pombe   313 FQHFFHSLKVLFTVPSNRRSLFIGCFLQWFQQFSGTNAIQYFSAIIF--QSVGFKNSISVSIVVG 375

  Fly   368 IMQVVATFVSTLVVDKLG-RRILLLASGISMA-ISTTAIGVYFFLQKQDAAQVVSLGW--LPVAS 428
            ....|.|.|:.:.:|::| |||||..|.:.:| ::..||..:|.  ..|..|..:.||  :.:||
pombe   376 ATNFVFTIVAFMFIDRIGRRRILLCTSAVMIAGLALCAIAYHFL--PADTTQNTNSGWQYVVLAS 438

  Fly   429 LCLFIIMFSIGYGPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFW 493
            :.:|:..::.|.|.:|| ...|||..:::......:...||:...:::.:|:.:.:.:...|||.
pombe   439 IIIFLASYASGIGNIPW-QQAELFPMEVRALGAGFSTAINWVGNLIISASFLTMMESITPTGTFA 502

  Fly   494 LFAGLTVVGVIFVYFAVPETKGKSLNEIQQEL 525
            ||||...||::..||..||..|.|:..|.:.|
pombe   503 LFAGFCFVGLVTSYFTYPELAGMSIENIHKLL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	102/376 (27%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	112/409 (27%)
itr2	NP_593320.1	Sugar_tr	84..534	CDD:278511	126/457 (28%)
itr2	NP_593320.1	MFS	86..519	CDD:119392	120/440 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	184	1.000	Inparanoid score	I1095
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13833
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860