DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10960 and Slc2a6

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_766247.2	Gene:	Slc2a6 / 227659	MGIID:	2443286	Length:	497	Species:	Mus musculus

Alignment Length:	456	Identity:	138/456 - (30%)
Similarity:	245/456 - (53%)	Gaps:	25/456 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 YVAALAAAGGAFAAGTVLGWTSPAETEIVDRGEGYDFP---VDKDQFSWVGSAMTLGAACVCIPI 145
            ::|..||..|.|:.|..|.:|||...|:....:    |   :||.|.||.||..|||||...:..
Mouse    38 FLATFAAVLGNFSFGYALVYTSPVIPELKLSSD----PALHLDKIQASWFGSVFTLGAAAGGLSA 98

  Fly   146 GFLINMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLYASRFILGIAGGAFCVTAPMYTGEIAQKE 210
            ..|.:::|||.:::|..:|..:|:.::..|..:.||...|.:.|.|||......|:|..|||..:
Mouse    99 MLLNDLLGRKLSIMFSAVPSAIGYAIMAGARGLWMLLLGRMLTGFAGGLTAACIPVYVSEIAPPD 163

  Fly   211 IRGTLGSFFQLMITIGILFVYAVGAGVKIFWLSIICGILP-LIFGAIFFFMPESPTYLVSKDRSE 274
            :||.||:..|||...|.|.:||:|..:...||: :.|..| ||...:..|||.||.:|:||.|.|
Mouse   164 VRGALGATPQLMAVFGSLSLYALGLLLPWRWLA-VAGEGPVLIMILLLSFMPNSPRFLLSKSRDE 227

  Fly   275 NAIKSIQWLRGKEYDYEPELAELRETDRETKANKVNVWAALNRPVTRKALAISMGLMFFQQVCGI 339
            .|::::.|||. :.:...|..::::..|. ::::|: ||....|...:.:.|::.:.|.||:.||
Mouse   228 EALQALTWLRA-DSEVHWEFEQIQDNVRR-QSSRVS-WAEAREPRVYRPVLIAVLMRFLQQLTGI 289

  Fly   340 NAVIFYASRIFLEANTGIEAEWATILIGIMQVVATFVSTLVVDKLGRRILLLASGISMAISTTAI 404
            ..::.|...||...:..:.::....::|.:::::..::.:.:|..||::||..|...|..:...:
Mouse   290 TPILVYLQTIFDNTSVVLPSQQDAAIVGAVRLLSVLIAAVTMDLAGRKVLLYVSASVMFAANLTL 354

  Fly   405 GVYFF-----LQKQDAAQVVSLG--------WLPVASLCLFIIMFSIGYGPVPWLMMGELFATDI 456
            |:|..     |......::|:||        .:|:.:..|||:.:::|:||:.||:|.|:.....
Mouse   355 GLYVQFVPRPLTPNSTVEIVTLGDTAFNYLTLIPLLATMLFIMGYAMGWGPITWLLMSEVLPLRA 419

  Fly   457 KGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVGVIFVYFAVPETKGKSLNEI 521
            :|.|..|....:||.|||:|..|:...:..|:...|:.|:.:.::.::|....||||:|:||.:|
Mouse   420 RGVASGLCVLVSWLTAFVLTNYFLLAVNAFGLQVPFFFFSAICLLSLLFTGCCVPETRGRSLEQI 484

  Fly   522 Q 522
            :
Mouse   485 E 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	111/373 (30%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	119/406 (29%)
Slc2a6	NP_766247.2	Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS	38..483	CDD:391944	137/452 (30%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	284..290		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834154
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm8886
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.750